YEATS4 - YEATS domain containing 4 Gene

Homo sapiens

Also known as YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik

Gene ID: 8089 | Gene type: protein coding

About YEATS4

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,359,743-69,462,793 (from NCBI)

This gene has 5 transcripts (splice variants) and 207 orthologues. Broad expression in testis (RPKM 7.3), bone marrow (RPKM 4.6) and 25 other tissues.

Summary

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

YEATS4 Products(2)

mRNA	Protein	Name
NM_001300950.2	NP_001287879.1	YEATS domain-containing protein 4 isoform 2
NM_006530.4	NP_006521.1	YEATS domain-containing protein 4 isoform 1

YEATS4 Protein Structure

YEATS

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

YEATS domain-containing protein 4

NuMA binding protein 1

YEATS4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	YEATS4	O95619	TPM1	Homo sapiens	P09493-10	Validated Y2H	32296183
Intra	YEATS4	O95619	ANKK1	Homo sapiens	Q8NFD2	Validated Y2H	32296183
Intra	YEATS4	O95619	TACC1	Homo sapiens	O75410	Y2H	11903063
Intra	YEATS4	O95619	TACC1	Homo sapiens	O75410	Anti Bait CoIP	11903063

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glioma

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Macular Dystrophy, Patterned, 3

Martinique Crinkled Retinal Pigment Epitheliopathy	Patterned Macular Dystrophy 3
MDPT3	Mcrpe

Pleomorphic Liposarcoma

Pls	Liposarcoma Pleomorphic
Liposarcoma, Pleomorphic

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152243	YEATS4 binder-1		/	Unkown
HY-152242	YEATS4-IN-1		/	Unkown
HY-RS15921	YEATS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	YEATS4	MGD	MGI:1927224
Felis catus	YEATS4	VGNC	VGNC:67135
Canis familiaris	YEATS4	VGNC	VGNC:48483
Rattus norvegicus	YEATS4	RGD	RGD:1305741
Bos taurus	YEATS4	VGNC	VGNC:37021

Name
Email *

	Sorry, but the email address you supplied was invalid.