ZBP1 - Z-DNA binding protein 1 Gene

Homo sapiens

Also known as DAI; DLM1; DLM-1; C20orf183

Gene ID: 81030 | Gene type: protein coding

About ZBP1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,603,852-57,620,426 (from NCBI)

This gene has 9 transcripts (splice variants) and 83 orthologues. Biased expression in spleen (RPKM 3.6), appendix (RPKM 3.2) and 13 other tissues.

Summary

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

ZBP1 Products(5)

mRNA	Protein	Name
NM_001160417.2	NP_001153889.1	Z-DNA-binding protein 1 isoform b
NM_001160418.2	NP_001153890.1	Z-DNA-binding protein 1 isoform c
NM_001160419.3	NP_001153891.1	Z-DNA-binding protein 1 isoform d
NM_001323966.2	NP_001310895.1	Z-DNA-binding protein 1 isoform e
NM_030776.3	NP_110403.2	Z-DNA-binding protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	17618271	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	34192517	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19095800	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19590578	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	34192517	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	32200799	GOA
involved in positive regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	32200799	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16876127	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17618271	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16876127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBP1 Protein Structure

z-alpha

RHIM

0
100
200
300
400
429 a.a.

Protein Preferred Names

Protein Names

Z-DNA-binding protein 1

DNA-dependent activator of IRFs

Recombinant ZBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71436	ZBP1 Protein, Human (His)	Q9H171-1 (M1-S149)	≥95%

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Zika Virus Congenital Syndrome

Zikv Congenital Infection

Variola Minor

Alastrim	Cottonpox
Milkpox	Whitepox

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144873	AVJ16		99.60%	Unkown
HY-162424	ZBP1/RIP3/MLKL activator 1	Activator	/	Unkown
HY-RS15958	ZBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZBP1	RGD	RGD:619956
Macaca mulatta	ZBP1	VGNC	VGNC:79013
Mus musculus	ZBP1	MGD	MGI:1927449
Canis familiaris	ZBP1	VGNC	VGNC:54745
Felis catus	ZBP1	VGNC	VGNC:81262
Bos taurus	ZBP1	VGNC	VGNC:37056
Others	ZBP1	NCBI

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