PLA2G12A - phospholipase A2 group XIIA Gene

Homo sapiens

Also known as GXII; ROSSY; PLA2G12

Gene ID: 81579 | Gene type: protein coding

About PLA2G12A

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:109,709,989-109,730,070 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.6), prostate (RPKM 9.6) and 25 other tissues.

Summary

Secreted Phospholipase A2 (sPLA2) Enzymes liberate arachidonic acid from Phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from Other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

PLA2G12A Products(1)

mRNA	Protein	Name
NM_030821.5	NP_110448.2	group XIIA secretory phospholipase A2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G12A Protein Structure

PLA2G12

0
100
189 a.a.

Protein Preferred Names

Protein Names

group XIIA secretory phospholipase A2

GXII sPLA2

PLA2G12A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLA2G12A	Q9BZM1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PLA2G12A	Q9BZM1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PLA2G12A	Q9BZM1	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Coenzyme Q10 Deficiency, Primary, 9

COQ10D9

Primary Coenzyme Q10 Deficiency 9

Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome	COFS1
Pena-Shokeir Syndrome Type 2	Cofs
Pena-Shokeir Syndrome, Type Ii	Cerebrooculofacioskeletal Syndrome
Cerebro-Oculo-Facio-Skeletal Syndrome 1	Pena Shokeir Syndrome Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10617	PLA2G12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLA2G12A	VGNC	VGNC:64197
Bos taurus	PLA2G12A	VGNC	VGNC:32954
Macaca mulatta	PLA2G12A	VGNC	VGNC:76058
Rattus norvegicus	PLA2G12A	RGD	RGD:1304662
Mus musculus	PLA2G12A	MGD	MGI:1913600

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