AKAP1 - A-kinase anchoring protein 1 Gene

Homo sapiens

Also known as AKAP; PRKA1; AKAP84; TDRD17; AKAP121; AKAP149; D-AKAP1; PPP1R43; SAKAP84

Gene ID: 8165 | Gene type: protein coding

About AKAP1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:57,085,246-57,121,344 (from NCBI)

This gene has 19 transcripts (splice variants) and 229 orthologues. Broad expression in testis (RPKM 41.4), heart (RPKM 27.0) and 24 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]

AKAP1 Products(8)

mRNA	Protein	Name
NM_001242902.1	NP_001229831.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001242903.1	NP_001229832.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370423.1	NP_001357352.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370424.1	NP_001357353.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370425.1	NP_001357354.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370426.1	NP_001357355.1	A-kinase anchor protein 1, mitochondrial precursor
NM_001370427.1	NP_001357356.1	A-kinase anchor protein 1, mitochondrial precursor
NM_003488.4	NP_003479.1	A-kinase anchor protein 1, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12223483	GOA
enables protein kinase A regulatory subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IMP IMP: Inferred from mutant phenotype	31522117	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP1 Protein Structure

KH_1

TUDOR

0
200
400
600
800
903 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 1, mitochondrial

A kinase (PRKA) anchor protein 1

AKAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Anti Tag CoIP	33961781
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	TAP	24981860
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Anti Bait CoIP	24083380
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Filter Binding	16642035
Intra	AKAP1	Q92667	PRKAR2A	Homo sapiens	P13861	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00512	AKAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AKAP1	VGNC	VGNC:25779
Rattus norvegicus	AKAP1	RGD	RGD:620826
Macaca mulatta	AKAP1	VGNC	VGNC:69763
Felis catus	AKAP1	VGNC	VGNC:59710
Mus musculus	AKAP1	MGD	MGI:104729
Canis familiaris	AKAP1	VGNC	VGNC:37751

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