PRKAR2A - protein kinase cAMP-dependent type II regulatory subunit alpha Gene

Homo sapiens

Also known as PKR2; PRKAR2

Gene ID: 5576 | Gene type: protein coding

About PRKAR2A

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,744,591-48,847,874 (from NCBI)

This gene has 7 transcripts (splice variants), 283 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 11.3), colon (RPKM 10.8) and 25 other tissues.

Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

PRKAR2A Products(4)

mRNA	Protein	Name
NM_001321982.2	NP_001308911.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a
NM_001321983.2	NP_001308912.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform b
NM_001321989.2	NP_001308918.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform c
NM_004157.4	NP_004148.1	cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP-dependent protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	21812984	GOA
enables cAMP-dependent protein kinase regulator activity	IDA IDA: Inferred from direct assay	21812984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9473338	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	25097019	GOA
enables protein kinase A catalytic subunit binding	IPI IPI: Inferred from physical interaction	17911601	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	21423175	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	21812984	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with axoneme	IDA IDA: Inferred from direct assay	12475942	GOA
part of cAMP-dependent protein kinase complex	IDA IDA: Inferred from direct assay	12475942	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21423175	GOA
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	21812984	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21423175	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	17911601	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	25097019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAR2A Protein Structure

RIIa

cNMP_binding

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

cAMP-dependent protein kinase type II-alpha regulatory subunit

cAMP-dependent protein kinase regulatory subunit RII alpha

PRKAR2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKAR2A	P13861	AKAP1	Homo sapiens	Q92667	Anti Bait CoIP	24083380
Intra	PRKAR2A	P13861	AKAP3	Homo sapiens	O75969	Pull Down	11278869

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome	NNMS
Chondrodysplasia-Disorder Of Sex Development Syndrome	Nivelon Nivelon Mabille Syndrome

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11114	PRKAR2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRKAR2A	VGNC	VGNC:76407
Mus musculus	PRKAR2A	MGD	MGI:108025
Rattus norvegicus	PRKAR2A	RGD	RGD:3393
Felis catus	PRKAR2A	VGNC	VGNC:69053
Canis familiaris	PRKAR2A	VGNC	VGNC:44976
Bos taurus	PRKAR2A	VGNC	VGNC:33325

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