Tgfb2 - transforming growth factor, beta 2 Gene

Rattus norvegicus

Also known as TGF-B2

Gene ID: 81809 | Gene type: protein coding

About Tgfb2

Primary_assembly 13: 98,160,087-98,261,405 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 199 orthologues, 31 paralogues and is associated with 45 phenotypes. Biased expression in Lung (RPKM 13.), Muscle (RPKM 77.3) and 9 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of release of sequestered calcium ion into cytosol; and regulation of apoptotic process. Located in several cellular components, including basement membrane; secretory granule; and trans-Golgi network. Biomarker of diabetic neuropathy; myocardial infarction; and osteochondrodysplasia. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 4 and colorectal Cancer. Orthologous to human TGFB2 (transforming growth factor beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb2 Products(1)

mRNA	Protein	Name
NM_031131.2	NP_112393.2	transforming growth factor beta-2 proprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18406405	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18406405	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in digestive tract development	IEP IEP: Inferred from expression pattern	12815632	RGD
involved in embryonic neurocranium morphogenesis	IDA IDA: Inferred from direct assay	11002343	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	15927076	RGD
involved in frontal suture morphogenesis	IEP IEP: Inferred from expression pattern	12416537	RGD
involved in hindbrain development	IEP IEP: Inferred from expression pattern	11231055	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	16479080	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	11245570	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11002343	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15944186	RGD
involved in negative regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	12876066	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	16479313	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16532270	RGD
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11014222	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11002343	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	15899155	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	15746252	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	12130550	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	16217485	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	16479313	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	11956143	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15746252	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	16439574	RGD
involved in thyroid gland development	IEP IEP: Inferred from expression pattern	18554691	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	16479080	RGD
located in cell surface	IDA IDA: Inferred from direct assay	12595240	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12595240	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	12595240	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12595240	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfb2 Protein Structure

TGFb_propeptide

TGF_beta_TGFB2

0
100
200
300
400
442 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta-2 proprotein

TGF beta 2 protein

TGF-beta-2

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990009	Nisevokitug	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14439	TGFB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14440	Tgfb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14441	Tgfb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb2	NCBI	NCBI:7042
Canis familiaris	Tgfb2	NCBI	NCBI:488596
Mus musculus	Tgfb2	NCBI	NCBI:21808
Macaca mulatta	Tgfb2	NCBI	NCBI:707540

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