Tgfb2 - transforming growth factor, beta 2 Gene

Mus musculus

Also known as Tgfb-2; Tgf-beta2

Gene ID: 21808 | Gene type: protein coding

About Tgfb2

Chromosome 1: 186,354,989-186,438,186 reverse strand.GRCm39:CM000994.3

This gene has 6 transcripts (splice variants), 199 orthologues, 32 paralogues and is associated with 122 phenotypes. Broad expression in limb E14.5 (RPKM 8.), CNS E11.5 (RPKM 3.4) and 17 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

Tgfb2 Products(2)

mRNA	Protein	Name
NM_001329107.1	NP_001316036.1	transforming growth factor beta-2 proprotein isoform 2 precursor
NM_009367.4	NP_033393.2	transforming growth factor beta-2 proprotein isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14985127	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of activation-induced cell death of T cells	IDA IDA: Inferred from direct assay	8206089	MGI
involved in ascending aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in atrial septum morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in atrial septum primum morphogenesis	IMP IMP: Inferred from mutant phenotype	11390347	MGI
involved in atrioventricular valve morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	15528466	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	15528466	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	12393102	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
acts upstream of or within cartilage condensation	IGI IGI: Inferred from genetic interaction	8565825	MGI
involved in cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in dopamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	16257223	MGI
involved in embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in endocardial cushion fusion	IMP IMP: Inferred from mutant phenotype	11390347	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	11390347	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	11784073	MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	8206089	MGI
involved in face morphogenesis	IEP IEP: Inferred from expression pattern	18498113	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	15630473	MGI
involved in hair follicle development	IMP IMP: Inferred from mutant phenotype	10433821	MGI
involved in hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	10433821	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15528466	MGI
acts upstream of or within heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	21780244	MGI
involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	11390347	MGI
involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	14707111	MGI
involved in inner ear development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in male gonad development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in membranous septum morphogenesis	IMP IMP: Inferred from mutant phenotype	11390347	MGI
involved in negative regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	19161227	MGI
acts upstream of or within negative regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	21780244	MGI
involved in negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19161227	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	21984612	MGI
involved in neural retina development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in neuron development	IMP IMP: Inferred from mutant phenotype	16257223	MGI
acts upstream of or within neuron fate commitment	IDA IDA: Inferred from direct assay	15744664	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	22186728	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in pericyte cell differentiation	IMP IMP: Inferred from mutant phenotype	28329690	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	11390347	MGI
involved in positive regulation of GTP binding	IDA IDA: Inferred from direct assay	21984612	MGI
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	12773577	MGI
acts upstream of or within positive regulation of activation-induced cell death of T cells	IDA IDA: Inferred from direct assay	8206089	MGI
involved in positive regulation of cardiac epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	22186728	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	14707111	MGI
involved in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19161227	MGI
involved in positive regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	21984612	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	8206089	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18498113	MGI
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	21984612	MGI
involved in pulmonary valve morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21984612	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12393102	MGI
involved in regulation of apoptotic process involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	11390347	MGI
acts upstream of or within regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	21780244	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	15531369	MGI
involved in skeletal system development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in somatic stem cell division	IDA IDA: Inferred from direct assay	14707111	MGI
involved in substantia propria of cornea development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12773577	MGI
involved in uterus development	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	9217007	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16257223	MGI
located in endosome	IDA IDA: Inferred from direct assay	21266196	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	8164195	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	16257223	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfb2 Protein Structure

TGFb_propeptide

TGF_beta_TGFB2

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

transforming growth factor beta-2 proprotein

Recombinant Tgfb2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70649	TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293)	P27090 (A303-S414)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990009	Nisevokitug	Inhibitor	97.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14439	TGFB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14440	Tgfb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14441	Tgfb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb2	NCBI	NCBI:7042
Canis familiaris	Tgfb2	NCBI	NCBI:488596
Rattus norvegicus	Tgfb2	NCBI	NCBI:81809
Macaca mulatta	Tgfb2	NCBI	NCBI:707540

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