RAB1B - RAB1B, member RAS oncogene family Gene

Homo sapiens

Gene ID: 81876 | Gene type: protein coding

About RAB1B

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,268,639-66,277,492 (from NCBI)

This gene has 2 transcripts (splice variants), 235 orthologues and 68 paralogues. Ubiquitous expression in prostate (RPKM 64.5), fat (RPKM 64.0) and 25 other tissues.

Summary

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

RAB1B Products(1)

mRNA	Protein	Name
NM_030981.3	NP_112243.1	ras-related protein Rab-1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15796781	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	26209634	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI IGI: Inferred from genetic interaction	21680502	GOA
NOT involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in positive regulation of glycoprotein metabolic process	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	20545908	GOA
involved in virion assembly	IGI IGI: Inferred from genetic interaction	21680502	GOA
NOT involved in virion assembly	IMP IMP: Inferred from mutant phenotype	21680502	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	20545908	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB1B Protein Structure

Ras

0
100
201 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-1B

small GTP-binding protein

RAB1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB1B	Q9H0U4	OCRL	Homo sapiens	Q01968	FPS	21378754
Intra	RAB1B	Q9H0U4	RABIF	Homo sapiens	P47224	Anti Tag CoIP	28514442
Intra	RAB1B	Q9H0U4	RABIF	Homo sapiens	P47224	Y2H Prey Pooling	32296183
Intra	RAB1B	Q9H0U4	RABIF	Homo sapiens	P47224	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75993	RAB1B Protein, Human (HEK293, Fc)	Q9H0U4 (M1-G199)	≥95%

Related Diseases

Diseases

Alias

Hypotrichosis 3

HYPT3	Hypotrichosis Simplex Of The Scalp 2
Htss2	Hypotrichosis, Type 3

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Pontiac Fever

Septicemic Plague

Plague, Septicemic

Immunodeficiency 54

Natural Killer Cell Deficiency, Familial Isolated	Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency
IMD54	Nkcd
Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect	Nkgcd
Familial Isolated Natural Killer Cell Deficiency	Primary Immunodeficiency Due To Mcm4 Deficiency

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11529	RAB1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAB1B	VGNC	VGNC:56276
Rattus norvegicus	RAB1B	RGD	RGD:1642882
Mus musculus	RAB1B	MGD	MGI:1923558
Canis familiaris	RAB1B	VGNC	VGNC:52037

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