CAPZA1 - capping actin protein of muscle Z-line subunit alpha 1 Gene

Homo sapiens

Also known as CAPZ; CAZ1; CAPPA1

Gene ID: 829 | Gene type: protein coding

About CAPZA1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,619,832-112,671,616 (from NCBI)

This gene has 6 transcripts (splice variants), 145 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 69.5), appendix (RPKM 61.9) and 25 other tissues.

Summary

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

CAPZA1 Products(1)

mRNA	Protein	Name
NM_006135.3	NP_006126.1	F-actin-capping protein subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22891260	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell junction assembly	IMP IMP: Inferred from mutant phenotype	22891260	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of WASH complex	IDA IDA: Inferred from direct assay	19922875	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPZA1 Protein Structure

F-actin_cap_A

0
100
200
286 a.a.

Protein Preferred Names

Protein Names

F-actin-capping protein subunit alpha-1

Cap Z

CAPZA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAPZA1	P52907	CAPZB	Homo sapiens	P47756	Crosslink	30021884
Intra	CAPZA1	P52907	S100B	Homo sapiens	P04271	FPS	31837246
Intra	CAPZA1	P52907	S100A5	Homo sapiens	P33763	FPS	31837246
Intra	CAPZA1	P52907	S100A1	Homo sapiens	P23297	FPS	31837246
Intra	CAPZA1	P52907	S100P	Homo sapiens	P25815	FPS	31837246

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Patellar Tendinitis

Patellar Tendonitis

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01902	CAPZA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CAPZA1	VGNC	VGNC:26756
Macaca mulatta	CAPZA1	VGNC	VGNC:99862
Rattus norvegicus	CAPZA1	RGD	RGD:1587438
Felis catus	CAPZA1	VGNC	VGNC:80155
Mus musculus	CAPZA1	MGD	MGI:106227

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