S100A5 - S100 calcium binding protein A5 Gene

Homo sapiens

Also known as S100D

Gene ID: 6276 | Gene type: protein coding

About S100A5

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,537,147-153,543,685 (from NCBI)

This gene has 2 transcripts (splice variants), 351 orthologues and 21 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the Other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]

S100A5 Products(4)

mRNA	Protein	Name
NM_001394232.1	NP_001381161.1	protein S100-A5
NM_001394233.1	NP_001381162.1	protein S100-A5
NM_001394234.1	NP_001381163.1	protein S100-A5
NM_002962.2	NP_002953.2	protein S100-A5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	19536568	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	19536568	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31837246	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19536568	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19536568	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12118070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A5 Protein Structure

S_100

0
92 a.a.

Protein Preferred Names

Protein Names

protein S100-A5

S100A5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	S100A5	P33763	CACYBP	Homo sapiens	Q9HB71	FPS	31837246
Intra	S100A5	P33763	CACYBP	Homo sapiens	Q9HB71	ITC	31837246
Intra	S100A5	P33763	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A5	P33763	SLC8A1	Homo sapiens	P32418	FPS	31837246
Intra	S100A5	P33763	MYH9	Homo sapiens	P35579	FPS	31837246
Intra	S100A5	P33763	CAPZA1	Homo sapiens	P52907	FPS	31837246
Intra	S100A5	P33763	TP53	Homo sapiens	P04637	FPS	31837246
Intra	S100A5	P33763	MDM4	Homo sapiens	O15151	FPS	31837246

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epidermoid Cysts

Epidermoid Cyst	Sebaceous Cyst
Epidermal Inclusion Cyst	Epidermal Cyst

Anaplastic Astrocytoma

Grade Iii Astrocytoma	Astrocytoma, Anaplastic
Grade Iii Astrocytic Tumor

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Pulmonary Systemic Sclerosis

Lung Disease With Systemic Sclerosis

Lung Involvement In Systemic Sclerosis

Psoriasis 7

PSORS7	Psoriasis 7, Susceptibility To
Psoriasis Susceptibility 7	Psoriasis
Psoriasis Vulgaris	Pv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12381	S100A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	S100A5	MGD	MGI:1338915
Felis catus	S100A5	VGNC	VGNC:64841
Canis familiaris	S100A5	VGNC	VGNC:45831
Rattus norvegicus	S100A5	RGD	RGD:1308996
Bos taurus	S100A5	VGNC	VGNC:34245
Macaca mulatta	S100A5	VGNC	VGNC:76959
Others	S100A5	NCBI

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