CAPZB - capping actin protein of muscle Z-line subunit beta Gene

Homo sapiens

Also known as CAPB; CAPZ; CAPPB

Gene ID: 832 | Gene type: protein coding

About CAPZB

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,338,775-19,485,539 (from NCBI)

This gene has 15 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in appendix (RPKM 43.9), lymph node (RPKM 41.5) and 25 other tissues.

Summary

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

CAPZB Products(5)

mRNA	Protein	Name
NM_001206540.3	NP_001193469.1	F-actin-capping protein subunit beta isoform 2
NM_001206541.3	NP_001193470.1	F-actin-capping protein subunit beta isoform 3
NM_001282162.2	NP_001269091.1	F-actin-capping protein subunit beta isoform 4
NM_001313932.2	NP_001300861.1	F-actin-capping protein subunit beta isoform 5
NM_004930.5	NP_004921.1	F-actin-capping protein subunit beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	28493397	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26618866	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of WASH complex	IDA IDA: Inferred from direct assay	19922875	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPZB Protein Structure

F_actin_cap_B

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

F-actin-capping protein subunit beta

capZ beta

CAPZB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAPZB	P47756	CAPZA1	Homo sapiens	P52907	Anti Tag CoIP	33961781
Intra	CAPZB	P47756	CAPZA1	Homo sapiens	P52907	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Progressive Pseudorheumatoid Dysplasia

Progressive Pseudorheumatoid Arthropathy Of Childhood	Arthropathy, Progressive Pseudorheumatoid, Of Childhood
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy	Ppd
Ppac	Sedt-Pa
Spondyloepiphyseal Dysplasia Tarda-Progressive Arthropathy Syndrome	PPRD
Progressive Pseudorheumatoid Chondrodysplasia	Spondyloepiphyseal Dysplasia Tarda - Progressive Arthropathy
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy
Dysplasia, Pseudorheumatoid, Progressive

Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ

Hemoglobin E Disease

Hemoglobin E

Hb-E Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01904	CAPZB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CAPZB	VGNC	VGNC:52114
Macaca mulatta	CAPZB	VGNC	VGNC:70539
Rattus norvegicus	CAPZB	RGD	RGD:1359099
Mus musculus	CAPZB	MGD	MGI:104652
Bos taurus	CAPZB	VGNC	VGNC:26759
Felis catus	CAPZB	VGNC	VGNC:60362

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