Mchr1 - melanin-concentrating hormone receptor 1 Gene

Rattus norvegicus

Also known as Slc1; Gpr24; Mch-1r

Gene ID: 83567 | Gene type: protein coding

About Mchr1

Primary_assembly 7: 112,761,554-112,764,032 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 241 orthologues, 50 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 31.9), Muscle (RPKM 4.3) and 2 other tissues.

Summary

Enables hormone binding activity; melanin-concentrating hormone receptor activity; and protein C-terminus binding activity. Involved in cell surface receptor signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 Products(1)

mRNA	Protein	Name
NM_031758.1	NP_113946.1	melanin-concentrating hormone receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone binding	IDA IDA: Inferred from direct assay	12505154	RGD
enables melanin-concentrating hormone receptor activity	IDA IDA: Inferred from direct assay	12505154	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16945926	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15117878	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	15117878	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	10559938	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mchr1 Protein Structure

7tmA_MCHR1

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

melanin-concentrating hormone receptor 1

G-protein coupled receptor 24	MCH receptor 1
MCH-R1	MCH1R
MCHR	MCHR-1
SLC-1	somatostatin receptor-like protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-U00257	AZD1979	Antagonist	98.09%	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107625A	SNAP 94847 hydrochloride	Inhibitor	99.90%	Unkown
HY-100321	MCHR1 antagonist 2		98.27%	Unkown
HY-P1204	[Ala17]-MCH	Agonist	98.28%	Unkown
HY-12433	BMS-819881		/	Unkown
HY-100318	NGD-4715	Antagonist	/	Unkown
HY-101699	AMG-076 free base	Antagonist	/	Unkown
HY-107625	SNAP 94847	Antagonist	/	Unkown
HY-107626A	ATC0065 free base	Antagonist	/	Unkown
HY-116031	ATC0175 free base	Antagonist	/	Unkown
HY-120608	BMS-814580	Inhibitor	/	Unkown
HY-136152	MCHR1 antagonist 3	Antagonist	/	Unkown
HY-161899	MCHR1 antagonist 4	Antagonist	/	Unkown
HY-P1204A	[Ala17]-MCH TFA	Agonist	/	Unkown
HY-RS08225	MCHR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08226	Mchr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08227	Mchr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101699A	AMG-076	Antagonist	/	Unkown
HY-107626	ATC0065	Antagonist	/	Unkown
HY-U00353	MCHR1 antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mchr1	NCBI	NCBI:2847

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