Apba1 - amyloid beta precursor protein binding family A member 1 Gene

Rattus norvegicus

Also known as Mint1

Gene ID: 83589 | Gene type: protein coding

About Apba1

Summary

Enables PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within several processes, including amino acid transport; in utero embryonic development; and intracellular protein transport. Located in dendritic spine and plasma membrane. Part of protein-containing complex. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Apba1 Products(1)

mRNA	Protein	Name
NM_031779.3	NP_113967.2	amyloid-beta A4 precursor protein-binding family A member 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15024025	RGD
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	12196555	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	9395480	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9395480	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17084383	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9395480	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	25378388	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	9395480	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amyloid-beta A4 precursor protein-binding family A member 1

adapter protein X11alpha	amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
amyloid beta (A4) precursor protein-binding, family A, member 1	mint-1
neuron-specific X11 pro

Apba1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Apba1	O35430	Stxbp1	Rattus norvegicus	P61765	Anti Bait CoIP	9395480
Intra	Apba1	O35430	Stxbp1	Rattus norvegicus	P61765	Pull Down	9395480
Intra	Apba1	O35430	Stx1a	Rattus norvegicus	P32851	Pull Down	9395480
Intra	Apba1	O35430	Stx1a	Rattus norvegicus	P32851	Pull Down	16763567
Intra	Apba1	O35430	Stx1a	Rattus norvegicus	P32851	Anti Bait CoIP	9395480

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00802	APBA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W751932	Carboxy-EG6-undecanethiol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apba1	NCBI	NCBI:320

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