Stx1a - syntaxin 1A Gene

Rattus norvegicus

Gene ID: 116470 | Gene type: protein coding

About Stx1a

Summary

Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle exocytosis. Located in several cellular components, including actomyosin; presynaptic active zone membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in glutamatergic synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Apr 2022]

Stx1a Products(1)

mRNA	Protein	Name
NM_053788.3	NP_446240.2	syntaxin-1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent protein binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables SNARE binding	IDA IDA: Inferred from direct assay	7553862	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	7698987	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables myosin binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables myosin head/neck binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8567678	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	16030255	RGD
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	16030255	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	17301173	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in SNARE complex assembly	IMP IMP: Inferred from mutant phenotype	9671503	RGD
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	18703708	RGD
involved in positive regulation of calcium ion-dependent exocytosis	IDA IDA: Inferred from direct assay	17301173	RGD
involved in positive regulation of catecholamine secretion	IDA IDA: Inferred from direct assay	20484665	RGD
involved in positive regulation of exocytosis	IDA IDA: Inferred from direct assay	11331586	RGD
involved in positive regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	12183029	RGD
involved in positive regulation of norepinephrine secretion	IDA IDA: Inferred from direct assay	18167541	RGD
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	12093152	RGD
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	16030255	RGD
involved in response to gravity	IDA IDA: Inferred from direct assay	15076716	RGD
involved in synaptic vesicle docking	IEP IEP: Inferred from expression pattern	1321498	RGD
involved in synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	7901002	RGD
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	7901002	RGD
involved in synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	7901002	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	26903802	RGD
located in actomyosin	IDA IDA: Inferred from direct assay	16030255	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	7901002	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	7901002	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17301173	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	26903802	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	26903802	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	8301329	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12093152	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19255244	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15537656	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	7860636	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	14645230	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IMP IMP: Inferred from mutant phenotype	9671503	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA IDA: Inferred from direct assay	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IDA IDA: Inferred from direct assay	19132534	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	17301173	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

syntaxin-1A

P35A	neuron-specific antigen HPC-1
synaptotagmin-associated 35 kDa protein	syntaxin 1A (brain)
syntaxin 1A (brain)-like

Stx1a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Stx1a	P32851	SNAP47	Homo sapiens	Q5SQN1	Confocal	26359495
Cross	Stx1a	P32851	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	26359495
Intra	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Pull Down	21193638
Intra	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Anti Bait CoIP	17717530
Intra	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	EPR	26876096
Intra	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Anti Bait CoIP	20489724
Intra	Stx1a	P32851	Snap25	Rattus norvegicus	P60881	Pull Down	10373452
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	EPR	26876096
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	X-Ray Diffraction	10746715
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	Fluorescence	18337752
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	ITC	21193638
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	Anti Tag CoIP	26359495
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	ITC	18337752
Intra	Stx1a	P32851	Stxbp1	Rattus norvegicus	P61765	Pull Down	21193638
Intra	Stx1a	P32851	Snap25	Rattus norvegicus	P60881-2	FRET	18275821
Intra	Stx1a	P32851	Cadps	Rattus norvegicus	Q62717	Density Sedimentation	19805029
Cross	Stx1a	P32851	Snap25	Mus musculus	P60879	Comigration in SDS	19805029
Cross	Stx1a	P32851	Snap25	Mus musculus	P60879	Anti Bait CoIP	19703397
Intra	Stx1a	P32851	Vamp2	Rattus norvegicus	P63045	Pull Down	21193638

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13980	STX1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx1a	NCBI	NCBI:6804

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