TLN2 - talin 2 Gene

Homo sapiens

Also known as ILWEQ

Gene ID: 83660 | Gene type: protein coding

About TLN2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:62,390,550-62,844,631 (from NCBI)

This gene has 11 transcripts (splice variants), 226 orthologues and 2 paralogues. Broad expression in kidney (RPKM 12.9), brain (RPKM 11.8) and 19 other tissues.

Summary

This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

TLN2 Products(2)

mRNA	Protein	Name
NM_001394547.1	NP_001381476.1	talin-2
NM_015059.3	NP_055874.2	talin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10320934	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in presynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15479735	GOA
involved in presynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15479735	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLN2 Protein Structure

FERM_N

FERM_M

IRS

Talin_middle

VBS

I_LWEQ

0
400
800
1200
1600
2000
2400
2542 a.a.

Protein Preferred Names

Protein Names

talin-2

TLN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TLN2	Q9Y4G6	ITGB2	Homo sapiens	P05107	Far-WB	19234221
Intra	TLN2	Q9Y4G6	ITGB2	Homo sapiens	P05107	Pull Down	19234221
Intra	TLN2	Q9Y4G6	ITGB2	Homo sapiens	P05107	Anti Bait CoIP	19234221
Intra	TLN2	Q9Y4G6	ABL1	Homo sapiens	P00519	Pull Down	19234221

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Otospondylomegaepiphyseal Dysplasia, Autosomal Recessive

Osmed	Otospondylomegaepiphyseal Dysplasia
Chondrodystrophy With Sensorineural Deafness	Nance-Insley Syndrome
Nance-Sweeney Chondrodysplasia	OSMEDB
Insley-Astley Syndrome	Osmed Syndrome
Mega-Epiphyseal Dwarfism	Weissenbacher-Zweymuller Syndrome, Formerly
Wzs, Formerly	Nance Sweeney Chondrodysplasia
Oto-Spondylo-Mega-Epiphyseal Dysplasia	Oto-Spondylo-Megaepiphyseal Dysplasia
Megaepiphyseal Dwarfism

Aromatase Excess Syndrome

AEXS	Increased Aromatase Activity
Familial Hyperestrogenism	Hereditary Prepubertal Gynecomastia
Aromatase Activity, Increased	Familial Gynecomastia Due To Increased Aromatase Activity
Hereditary Gynecomastia	Gynecomastia, Familial
Familial Gynecomastia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14575	TLN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TLN2	VGNC	VGNC:35898
Felis catus	TLN2	VGNC	VGNC:66216
Macaca mulatta	TLN2	VGNC	VGNC:78385
Canis familiaris	TLN2	VGNC	VGNC:47402
Rattus norvegicus	TLN2	RGD	RGD:1565416
Mus musculus	TLN2	MGD	MGI:1917799

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