CD99L2 - CD99 molecule like 2 Gene

Homo sapiens

Also known as CD99B; MIC2L1

Gene ID: 83692 | Gene type: protein coding

About CD99L2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:150,766,336-150,898,668 (from NCBI)

This gene has 9 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 33.3), fat (RPKM 18.8) and 23 other tissues.

Summary

This gene encodes a cell-surface protein that is similar to CD99. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

CD99L2 Products(5)

mRNA	Protein	Name
NM_001184808.2	NP_001171737.1	CD99 antigen-like protein 2 isoform 4 precursor
NM_001242614.2	NP_001229543.1	CD99 antigen-like protein 2 isoform 5 precursor
NM_031462.4	NP_113650.2	CD99 antigen-like protein 2 isoform 1 precursor
NM_134445.4	NP_604394.1	CD99 antigen-like protein 2 isoform 3 precursor
NM_134446.4	NP_604395.1	CD99 antigen-like protein 2 isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD99L2 Protein Structure

CD99L2

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

CD99 antigen-like protein 2

MIC2 like 1

CD99L2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	26871637
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	26871637
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	26871637
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	CD99L2	Q8TCZ2	SGTA	Homo sapiens	O43765	Validated Y2H	26871637
Intra	CD99L2	Q8TCZ2	SGTA	Homo sapiens	O43765	Y2H Array	26871637
Intra	CD99L2	Q8TCZ2	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	CD99L2	Q8TCZ2	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	26871637
Intra	CD99L2	Q8TCZ2	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	26871637
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	26871637
Intra	CD99L2	Q8TCZ2	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	26871637
Intra	CD99L2	Q8TCZ2	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	CD99L2	Q8TCZ2	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	CD99L2	Q8TCZ2	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CD99L2	Q8TCZ2	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CD99L2	Q8TCZ2	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CD99L2	Q8TCZ2	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD99L2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72697	CD99L2 Protein, Human (HEK293, His)	Q8TCZ2-1 (D26-A188)	≥95%

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 65

DEE65	Epileptic Encephalopathy, Early Infantile, 65
Eiee65	Developmental And Epileptic Encephalopathy, 65
Early Infantile Epileptic Encephalopathy 65	Encephalopathy, Epileptic, Early Infantile, Type 65

Chronic Cervicitis

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02281	CD99L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD99L2	VGNC	VGNC:70823
Felis catus	CD99L2	VGNC	VGNC:60644
Bos taurus	CD99L2	VGNC	VGNC:106678
Rattus norvegicus	CD99L2	RGD	RGD:620896
Mus musculus	CD99L2	MGD	MGI:2177151
Canis familiaris	CD99L2	VGNC	VGNC:54128
Others	CD99L2	NCBI

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