CALN1 - calneuron 1 Gene

Homo sapiens

Also known as CABP8

Gene ID: 83698 | Gene type: protein coding

About CALN1

Cytogenetic location: 7q11.22 Genomic coordinates (GRCh38): 7:71,779,491-72,504,279 (from NCBI)

This gene has 6 transcripts (splice variants), 277 orthologues and 20 paralogues. Biased expression in brain (RPKM 8.4), adrenal (RPKM 3.0) and 1 other tissue.

Summary

This gene encodes a protein with high similarity to the calcium-binding proteins of the Calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CALN1 Products(3)

mRNA	Protein	Name
NM_001017440.3	NP_001017440.1	calcium-binding protein 8 isoform 2
NM_001363460.1	NP_001350389.1	calcium-binding protein 8 isoform 2
NM_031468.4	NP_113656.2	calcium-binding protein 8 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	19338761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALN1 Protein Structure

EF-hand_7

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

calcium-binding protein 8

calcium-binding protein CABP8

CALN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	CALN1	Q9BXU9	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	CALN1	Q9BXU9	SLPI	Homo sapiens	P03973	Y2H Prey Pooling	32296183
Intra	CALN1	Q9BXU9	SLPI	Homo sapiens	P03973	Y2H Array	32296183
Intra	CALN1	Q9BXU9	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	CALN1	Q9BXU9	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	CALN1	Q9BXU9	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

D-Glyceric Aciduria

D-Glyceric Acidemia	D-Glycericacidemia
Glycerate Kinase Deficiency	D-Glycerate Kinase Deficiency
Non Ketotic Hyperglycinemia Syndrome	Deficiency Of Glycerate Kinase
Hyperglycinemia, Non-Ketotic	D-GA

Deafness, Autosomal Recessive 39

DFNB39	Autosomal Recessive Nonsyndromic Deafness 39
Autosomal Recessive Deafness 39	Deafness, Autosomal Recessive, 39
Congenital Neurosensory Deafness Autosomal Recessive 39	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39	Deafness, Autosomal Recessive, Type 39

Drug Psychosis

Drug-Induced Psychosis	Drug-Induced Psychotic Disorder
Psychoses, Substance-Induced	Psychoses, Drug

Drug-Induced Mental Disorder

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01846	CALN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CALN1	VGNC	VGNC:82078
Mus musculus	CALN1	MGD	MGI:2155987
Rattus norvegicus	CALN1	RGD	RGD:1305843
Canis familiaris	CALN1	VGNC	VGNC:38674
Bos taurus	CALN1	VGNC	VGNC:26714

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