2. Gene
  3. USE1 - unconventional SNARE in the ER 1 Gene

USE1 - unconventional SNARE in the ER 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as D12; P31; SLT1; MDS032

Gene ID: 55850 | Gene type: protein coding

About USE1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,215,357-17,219,829 (from NCBI)

This gene has 9 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in brain (RPKM 7.1), fat (RPKM 6.8) and 25 other tissues.

Summary

Predicted to enable SNAP receptor activity. Predicted to be involved in several processes, including lysosomal transport; protein catabolic process; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

USE1 Products(1)

mRNA Protein Name
NM_018467.4 NP_060937.2 vesicle transport protein USE1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15029241 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15029241 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USE1 Protein Structure

Use1

Use1: Membrane fusion protein Use1 (4 - 255)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

vesicle transport protein USE1

Q-SNARE

USE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra USE1 Q9NZ43 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra USE1 Q9NZ43 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra USE1 Q9NZ43 CALN1 Homo sapiens Q9BXU9
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 CALN1 Homo sapiens Q9BXU9
Y2H Array
32296183
Intra USE1 Q9NZ43 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra USE1 Q9NZ43 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra USE1 Q9NZ43 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra USE1 Q9NZ43 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 CCM2L Homo sapiens Q9NUG4
Y2H Array
32296183
Intra USE1 Q9NZ43 CCM2L Homo sapiens Q9NUG4
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra USE1 Q9NZ43 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra USE1 Q9NZ43 APOL2 Homo sapiens Q9BQE5
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 APOL2 Homo sapiens Q9BQE5
Y2H Array
32296183
Intra USE1 Q9NZ43 CCDC70 Homo sapiens Q6NSX1
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 CCDC70 Homo sapiens Q6NSX1
Y2H Array
32296183
Intra USE1 Q9NZ43 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra USE1 Q9NZ43 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Pull Down
19369418
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Bait CoIP
19369418
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
33961781
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
28514442
Intra USE1 Q9NZ43 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
19369418
Intra USE1 Q9NZ43 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra USE1 Q9NZ43 STX4 Homo sapiens Q12846
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Childhood Malignant Schwannoma

Pediatric Mpnst

Childhood Neurofibrosarcoma
Anteroseptal Myocardial Infarction
Infantile Liver Failure Syndrome

Infantile Liver Failure
Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8

ARMD8

Macular Degeneration, Age-Related, Type 8
Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder
Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis
Pelger-Huet Anomaly

PHA

Pelger-Huët Anomaly

Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities

Pelger Huet Anomaly

Pelger-Huet Nuclear Anomaly
Dysostosis

Dysostoses
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-Y0338 Ethylene glycol,98% 99.90% Unkown
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-126047A (R,S)-Anatabine 98.34% Unkown
HY-131146 AMOZ Inhibitor 99.89% Unkown
HY-131144S AMOZ-d5 Inhibitor 99.0% Unkown
HY-D1821 Vari Fluor 750 Carboxylic acid（free acid） ≥95.0% Unkown
HY-139578 Ocarocoxib Inhibitor 99.94% Unkown
HY-121081 BAY-958 Inhibitor / Unkown
HY-126047AR (R,S)-Anatabine (Standard) / Unkown
HY-135711 PDE8B-IN-1 / Unkown
HY-161755 Anticancer agent 232 / Unkown
HY-D1822 Vari Fluor 555 Carboxylic acid（free acid） ≥96.0% Unkown
HY-D1823 Vari Fluor 647A Carboxylic acid（free acid） ≥98.0% Unkown
HY-D1824 Vari Fluor 488 Carboxylic acid（free acid） / Unkown
HY-D1825 Vari Fluor 532 Carboxylic acid（free acid） ≥95.0% Unkown
HY-D1826 Vari Fluor 594 Carboxylic acid（free acid） / Unkown
HY-D1827 Vari Fluor 660 Carboxylic acid（free acid） / Unkown
HY-D1828 Vari Fluor 640 Carboxylic acid（free acid） / Unkown
HY-D1829 Vari Fluor 568 Carboxylic acid（free acid） / Unkown
HY-D1830 Vari Fluor 680 Carboxylic acid（free acid） ≥97.0% Unkown
HY-P1378 β-Amyloid (1-43)(human) / Unkown
HY-P1378A β-Amyloid (1-43)(human) TFA / Unkown
HY-RS15512 USE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W143890 Etifenin / Unkown
HY-117831 NSC-79887 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus USE1 RGD RGD:1306660
Felis catus USE1 VGNC VGNC:66859
Bos taurus USE1 VGNC VGNC:107017
Mus musculus USE1 MGD MGI:1914273
Macaca mulatta USE1 VGNC VGNC:79892
Canis familiaris USE1 VGNC VGNC:48171
Others USE1 NCBI