RIOK1 - RIO kinase 1 Gene

Homo sapiens

Also known as RIO1; AD034; RRP10; bA288G3.1

Gene ID: 83732 | Gene type: protein coding

About RIOK1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,389,808-7,418,037 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 12.9), bone marrow (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]

RIOK1 Products(2)

mRNA	Protein	Name
NM_001348194.2	NP_001335123.1	serine/threonine-protein kinase RIO1 isoform 3
NM_031480.3	NP_113668.2	serine/threonine-protein kinase RIO1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21081503	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in maturation of SSU-rRNA	IMP IMP: Inferred from mutant phenotype	22072790	GOA
involved in positive regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	22072790	GOA
involved in ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	22072790	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21081503	GOA
part of methyltransferase complex	IMP IMP: Inferred from mutant phenotype	21081503	GOA
part of preribosome, small subunit precursor	IDA IDA: Inferred from direct assay	22072790	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIOK1 Protein Structure

RIO1

0
100
200
300
400
500
568 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase RIO1

Recombinant RIOK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76578	RIOK1 Protein, Human (sf9, His-GST)	Q9BRS2 (M1-K568)	≥95%

Related Diseases

Diseases

Alias

Cecum Carcinoma

Cecum Cancer	Caecum Carcinoma
Carcinoma Of Cecum	Cecal Cancer
Malignant Neoplasm Of Caecum	Malignant Tumor Of The Cecum

Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11988	RIOK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RIOK1	RGD	RGD:1306086
Macaca mulatta	RIOK1	VGNC	VGNC:76767
Mus musculus	RIOK1	MGD	MGI:1918590
Canis familiaris	RIOK1	VGNC	VGNC:54987
Bos taurus	RIOK1	VGNC	VGNC:50051
Felis catus	RIOK1	VGNC	VGNC:102503
Others	RIOK1	NCBI

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