NME5 - NME/NM23 family member 5 Gene

Homo sapiens

Also known as CILD48; NM23H5; RSPH23; NM23-H5

Gene ID: 8382 | Gene type: protein coding

About NME5

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,115,175-138,139,428 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 8 paralogues. Biased expression in testis (RPKM 15.2), kidney (RPKM 4.4) and 8 other tissues.

Summary

Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or within cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and ventricular system development. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]

NME5 Products(1)

mRNA	Protein	Name
NM_003551.3	NP_003542.1	nucleoside diphosphate kinase homolog 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	16313181	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	32185794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NME5 Protein Structure

NDK

Dpy-30

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

nucleoside diphosphate kinase homolog 5

IPIA-beta

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 48, Without Situs Inversus

CILD48

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09376	NME5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NME5	MGD	MGI:1922783
Macaca mulatta	NME5	VGNC	VGNC:84453
Felis catus	NME5	VGNC	VGNC:68504
Rattus norvegicus	NME5	RGD	RGD:1583004
Bos taurus	NME5	VGNC	VGNC:32127

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