TMEM120A - transmembrane protein 120A Gene

Homo sapiens

Also known as NET29; TACAN; TMPIT

Gene ID: 83862 | Gene type: protein coding

About TMEM120A

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,986,831-75,994,595 (from NCBI)

This gene has 15 transcripts (splice variants), 251 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 47.7), adrenal (RPKM 45.0) and 25 other tissues.

Summary

Predicted to enable ion channel activity. Involved in fat cell differentiation; protein heterooligomerization; and protein homooligomerization. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM120A Products(3)

mRNA	Protein	Name
NM_001317803.2	NP_001304732.1	ion channel TACAN isoform 2
NM_001363462.2	NP_001350391.1	ion channel TACAN isoform 3
NM_031925.3	NP_114131.1	ion channel TACAN isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	26024229	GOA
involved in protein heterooligomerization	IDA IDA: Inferred from direct assay	26024229	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	26024229	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ion channel TACAN

transmembrane protein induced by tumor necrosis factor alpha

TMEM120A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM120A	Q9BXJ8	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	DHRS7	Homo sapiens	Q9Y394	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	DHRS7	Homo sapiens	Q9Y394	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	LEPROT	Homo sapiens	O15243	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	LEPROT	Homo sapiens	O15243	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMEM88	Homo sapiens	Q6PEY1	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMEM88	Homo sapiens	Q6PEY1	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	TMEM88	Homo sapiens	Q6PEY1	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	TSPAN18	Homo sapiens	Q8WUV1	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	TSPAN18	Homo sapiens	Q8WUV1	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	TMEM120A	Q9BXJ8	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TMEM120A	Q9BXJ8	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TMEM120A	Q9BXJ8	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14656	TMEM120A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM120A	RGD	RGD:1311474
Felis catus	TMEM120A	VGNC	VGNC:66263
Macaca mulatta	TMEM120A	VGNC	VGNC:79333
Mus musculus	TMEM120A	MGD	MGI:2686991
Bos taurus	TMEM120A	VGNC	VGNC:35956
Canis familiaris	TMEM120A	VGNC	VGNC:54080

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