CDCA7 - cell division cycle associated 7 Gene

Homo sapiens

Also known as ICF3; JPO1

Gene ID: 83879 | Gene type: protein coding

About CDCA7

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:173,354,872-173,368,997 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 15.2), duodenum (RPKM 15.1) and 14 other tissues.

Summary

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

CDCA7 Products(2)

mRNA	Protein	Name
NM_031942.5	NP_114148.3	cell division cycle-associated protein 7 isoform 1
NM_145810.3	NP_665809.1	cell division cycle-associated protein 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11598121	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11598121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA7 Protein Structure

zf-4CXXC_R1

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

cell division cycle-associated protein 7

c-Myc target JPO1

Related Diseases

Diseases

Alias

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3

ICF3	Icf Syndrome 3
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome, Type 3

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1

Immunodeficiency Syndrome, Variable	ICF1
Ciid	Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16
Centromeric Instability, Immunodeficiency Syndrome	Icf Syndrome 1
Centromeric Instability Immunodeficiency Syndrome	Icf Syndrome
Variable Immune Deficiency With Centromeric Instability Of Chromosomes 1 9 And 16	Variable Immunodeficiency Syndrome
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome, Type 1	Common Variable Immunodeficiency
Chromosomal Instability

Hepatic Venoocclusive Disease With Immunodeficiency

VODI	Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatic Veno-Occlusive Disease With Immunodeficiency	Familial Veno-Occlusive Disease With Immunodeficiency
Veno-Occlusive Disease And Immunodeficiency Syndrome	Vodi Syndrome
Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02315	CDCA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02316	CDCA7L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDCA7	RGD	RGD:1309363
Macaca mulatta	CDCA7	VGNC	VGNC:70713
Bos taurus	CDCA7	VGNC	VGNC:27086
Mus musculus	CDCA7	MGD	MGI:1914203
Felis catus	CDCA7	VGNC	VGNC:60668

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