KCTD10 - potassium channel tetramerization domain containing 10 Gene

Homo sapiens

Also known as BTBD28; ULRO61; MSTP028; hBACURD3

Gene ID: 83892 | Gene type: protein coding

About KCTD10

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,448,655-109,477,300 (from NCBI)

This gene has 16 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 26.1), endometrium (RPKM 18.7) and 24 other tissues.

Summary

The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

KCTD10 Products(3)

mRNA	Protein	Name
NM_001317395.2	NP_001304324.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1
NM_001317399.2	NP_001304328.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 3
NM_031954.5	NP_114160.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	25401743	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25401743	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD10 Protein Structure

BTB_2

0
100
200
313 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

BTB/POZ domain-containing protein KCTD10

KCTD10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCTD10	Q9H3F6	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	KCTD10	Q9H3F6	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	KCTD10	Q9H3F6	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	32296183
Intra	KCTD10	Q9H3F6	TNFAIP1	Homo sapiens	Q13829	Y2H Array	32296183
Intra	KCTD10	Q9H3F6	KCTD13	Homo sapiens	Q8WZ19	Y2H Prey Pooling	32296183
Intra	KCTD10	Q9H3F6	KCTD13	Homo sapiens	Q8WZ19	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type	Methylmalonic Acidemia Cblb Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type	Methylmalonic Acidemia, Cblb Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type	Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type
Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb	Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb
Methylmalonic Aciduria Type Cblb	MMAB
Methylmalonic Aciduria Type B	Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B
Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B	Aciduria, Methylmalonic, Cblb Type
Methylmalonic Acidemia	Methylmalonic Aciduria

Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome	Sen Syndrome
SENS	Scalp Ear Nipple Syndrome
Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples	Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples
Indian Childhood Cirrhosis

Branchiooculofacial Syndrome

Branchio-Oculo-Facial Syndrome	BOFS
Bof Syndrome	Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome
Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome	Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging
Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging	Bofs Syndrome
Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07187	KCTD10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KCTD10	VGNC	VGNC:73893
Felis catus	KCTD10	VGNC	VGNC:63053
Canis familiaris	KCTD10	VGNC	VGNC:42300
Mus musculus	KCTD10	MGD	MGI:2141207
Rattus norvegicus	KCTD10	RGD	RGD:1591979
Bos taurus	KCTD10	VGNC	VGNC:30500

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