2. Gene
  3. KCTD13 - potassium channel tetramerization domain containing 13 Gene

KCTD13 - potassium channel tetramerization domain containing 13 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PDIP1; FKSG86; BACURD1; POLDIP1; hBACURD1

Gene ID: 253980 | Gene type: protein coding

About KCTD13

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,906,339-29,926,226 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues and 2 paralogues. Broad expression in testis (RPKM 12.8), brain (RPKM 4.9) and 23 other tissues.

Summary

Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of Rho protein signal transduction; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

KCTD13 Products(2)

mRNA Protein Name
NM_001410898.1 NP_001397827.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 2
NM_178863.5 NP_849194.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
19782033 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19782033 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
19782033 GOA
involved in negative regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
19782033 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19782033 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
19782033 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
19782033 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
19782033 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD13 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (43 - 133)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

BTB/POZ domain-containing protein KCTD13

KCTD13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KCTD13 Q8WZ19 MAT2A Homo sapiens P31153
Y2H Array
32814053
Intra KCTD13 Q8WZ19 MAT2A Homo sapiens P31153
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 MAT2A Homo sapiens P31153
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra KCTD13 Q8WZ19 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Anti Tag CoIP
33961781
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Anti Tag CoIP
28514442
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
25416956
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Y2H Array
25416956
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Anti Tag CoIP
19615732
Intra KCTD13 Q8WZ19 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra KCTD13 Q8WZ19 KCTD10 Homo sapiens Q9H3F6
Anti Tag CoIP
33961781
Intra KCTD13 Q8WZ19 KCTD10 Homo sapiens Q9H3F6
Validated Y2H
32296183
Intra KCTD13 Q8WZ19 KCTD10 Homo sapiens Q9H3F6
Anti Tag CoIP
19615732
Intra KCTD13 Q8WZ19 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra KCTD13 Q8WZ19 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 EXOSC5 Homo sapiens Q9NQT4
Validated Y2H
32296183
Intra KCTD13 Q8WZ19 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra KCTD13 Q8WZ19 CUL3 Homo sapiens Q13618
Validated Y2H
25416956
Intra KCTD13 Q8WZ19 CUL3 Homo sapiens Q13618
Y2H Array
25416956
Intra KCTD13 Q8WZ19 CUL3 Homo sapiens Q13618
Anti Tag CoIP
33961781
Intra KCTD13 Q8WZ19 FXR1 Homo sapiens P51114
Anti Tag CoIP
21653829
Intra KCTD13 Q8WZ19 FXR1 Homo sapiens P51114
Y2H Pooling
21653829
Intra KCTD13 Q8WZ19 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra KCTD13 Q8WZ19 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra KCTD13 Q8WZ19 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra KCTD13 Q8WZ19 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra KCTD13 Q8WZ19 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra KCTD13 Q8WZ19 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra KCTD13 Q8WZ19 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra KCTD13 Q8WZ19 ZMYND19 Homo sapiens Q96E35
Validated Y2H
25416956
Intra KCTD13 Q8WZ19 ZMYND19 Homo sapiens Q96E35
Y2H Prey Pooling
25416956
Intra KCTD13 Q8WZ19 BAG3 Homo sapiens O95817
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 BAG3 Homo sapiens O95817
Y2H Array
32814053
Intra KCTD13 Q8WZ19 BAG3 Homo sapiens O95817
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra KCTD13 Q8WZ19 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra KCTD13 Q8WZ19 FLNA Homo sapiens P21333-2
Validated Y2H
32814053
Intra KCTD13 Q8WZ19 FLNA Homo sapiens P21333-2
Y2H Array
32814053
Intra KCTD13 Q8WZ19 FLNA Homo sapiens P21333-2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Osteoarthritis

Osteoarthrosis

Degenerative Joint Disease

Hypertrophic Arthritis

Arthropathy

Degenerative Polyarthritis

Degenerative Arthritis

Osteoarthrosis And Allied Disorder

Arthritis, Degenerative

Oa

Osteoarthritis Deformans

Osteoarthrosis Deformans

Kashin-Beck Disease
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome

Sen Syndrome

SENS

Scalp Ear Nipple Syndrome

Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples

Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples

Indian Childhood Cirrhosis
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07190 KCTD13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KCTD13 RGD RGD:735189
Mus musculus KCTD13 MGD MGI:1923739
Macaca mulatta KCTD13 VGNC VGNC:104735
Bos taurus KCTD13 VGNC VGNC:30503
Canis familiaris KCTD13 VGNC VGNC:42302
Felis catus KCTD13 VGNC VGNC:63054