TNFAIP1 - TNF alpha induced protein 1 Gene

Homo sapiens

Also known as B12; B61; EDP1; BTBD34; hBACURD2

Gene ID: 7126 | Gene type: protein coding

About TNFAIP1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,335,761-28,347,009 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 21.1), spleen (RPKM 20.2) and 25 other tissues.

Summary

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]

TNFAIP1 Products(1)

mRNA	Protein	Name
NM_021137.5	NP_066960.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	19637314	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19782033	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in immune response	IEP IEP: Inferred from expression pattern	1370465	GOA
involved in negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19782033	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19782033	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	19782033	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19782033	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19637314	GOA
located in endosome	IDA IDA: Inferred from direct assay	19637314	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP1 Protein Structure

BTB_2

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

BTB/POZ domain-containing protein TNFAIP1

TNFAIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNFAIP1	Q13829	CAPN7	Homo sapiens	Q7Z479	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	CAPN7	Homo sapiens	Q7Z479	Y2H Array	25416956
Intra	TNFAIP1	Q13829	POLR1C	Homo sapiens	O15160	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	POLR1C	Homo sapiens	O15160	Y2H	21988832
Intra	TNFAIP1	Q13829	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	TNFAIP1	Q13829	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	TNFAIP1	Q13829	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	TNFAIP1	Q13829	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	TNFAIP1	Q13829	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	TNFAIP1	Q13829	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	TNFAIP1	Q13829	CAPN7	Homo sapiens	Q9Y6W3	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	KCTD13	Homo sapiens	Q8WZ19	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	KCTD13	Homo sapiens	Q8WZ19	Y2H Array	32296183
Intra	TNFAIP1	Q13829	KCTD13	Homo sapiens	Q8WZ19	Y2H Prey Pooling	32296183
Intra	TNFAIP1	Q13829	CUL3	Homo sapiens	Q13618	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	KCTD13	Homo sapiens	Q8WZ19	Anti Tag CoIP	33961781
Intra	TNFAIP1	Q13829	CUL3	Homo sapiens	Q13618	Y2H Array	25416956
Intra	TNFAIP1	Q13829	KCTD13	Homo sapiens	Q8WZ19	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	KCTD10	Homo sapiens	Q9H3F6	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	KCTD10	Homo sapiens	Q9H3F6	Y2H Prey Pooling	32296183
Intra	TNFAIP1	Q13829	KCTD10	Homo sapiens	Q9H3F6	Anti Tag CoIP	33961781
Intra	TNFAIP1	Q13829	KCTD10	Homo sapiens	Q9H3F6	Y2H Array	32296183
Intra	TNFAIP1	Q13829	GATM	Homo sapiens	P50440	Validated Y2H	32814053
Intra	TNFAIP1	Q13829	GATM	Homo sapiens	P50440	Y2H Pooling	32814053
Intra	TNFAIP1	Q13829	GATM	Homo sapiens	P50440	Y2H Array	32814053
Intra	TNFAIP1	Q13829	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	GRB2	Homo sapiens	P62993	Y2H Array	32814053
Intra	TNFAIP1	Q13829	GRB2	Homo sapiens	P62993	Y2H Pooling	32814053
Intra	TNFAIP1	Q13829	GRB2	Homo sapiens	P62993	Validated Y2H	32814053
Intra	TNFAIP1	Q13829	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	RHOB	Homo sapiens	P62745	Anti Tag CoIP	19637314
Intra	TNFAIP1	Q13829	RHOB	Homo sapiens	P62745	Confocal	19637314
Intra	TNFAIP1	Q13829	SRC	Homo sapiens	P12931	Validated Y2H	32814053
Intra	TNFAIP1	Q13829	SRC	Homo sapiens	P12931	Y2H Array	32814053
Intra	TNFAIP1	Q13829	SRC	Homo sapiens	P12931	Y2H Pooling	32814053
Intra	TNFAIP1	Q13829	EPM2AIP1	Homo sapiens	Q7L775	Y2H Array	25416956
Intra	TNFAIP1	Q13829	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	EPM2AIP1	Homo sapiens	Q7L775	Y2H Prey Pooling	25416956
Intra	TNFAIP1	Q13829	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	ARMC7	Homo sapiens	Q9H6L4	Y2H Array	25416956
Intra	TNFAIP1	Q13829	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	32296183
Intra	TNFAIP1	Q13829	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	TNFAIP1	Q13829	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	TNFAIP1	Q13829	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	TNFAIP1	Q13829	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	TNFAIP1	Q13829	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	TNFAIP1	Q13829	STK16	Homo sapiens	O75716	Validated Y2H	25416956
Intra	TNFAIP1	Q13829	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
Intra	TNFAIP1	Q13829	CARD9	Homo sapiens	Q9H257	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 16

PCH16	Pontocerebellar Hypoplasia Type 16
Pontocerebellar Hypoplasia 16	Doid:0112333

Neurotic Excoriation

Factitious Skin Disease	Dermatitis Artefacta
Dermatitis Factitia	Dermatitis Ficta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14787	TNFAIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFAIP1	MGD	MGI:104961
Felis catus	TNFAIP1	VGNC	VGNC:66397
Rattus norvegicus	TNFAIP1	RGD	RGD:3877
Canis familiaris	TNFAIP1	VGNC	VGNC:47648
Bos taurus	TNFAIP1	VGNC	VGNC:36154
Macaca mulatta	TNFAIP1	VGNC	VGNC:78578

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