TNFAIP1 - TNF alpha induced protein 1 Gene

Homo sapiens

Also known as B12; B61; EDP1; BTBD34; hBACURD2

Gene ID: 7126 | Gene type: protein coding

About TNFAIP1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,335,761-28,347,009 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 21.1), spleen (RPKM 20.2) and 25 other tissues.

Summary

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]

TNFAIP1 Products(1)

mRNA	Protein	Name
NM_021137.5	NP_066960.1	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19615732	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	19637314	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19782033	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in immune response	IEP IEP: Inferred from expression pattern	1370465	GOA
involved in negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	19782033	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19782033	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19782033	GOA
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	19782033	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19782033	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19637314	GOA
located in endosome	IDA IDA: Inferred from direct assay	19637314	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP1 Protein Structure

BTB_2

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

BTB/POZ domain-containing protein TNFAIP1

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 16

PCH16	Pontocerebellar Hypoplasia Type 16
Pontocerebellar Hypoplasia 16	Doid:0112333

Neurotic Excoriation

Factitious Skin Disease	Dermatitis Artefacta
Dermatitis Factitia	Dermatitis Ficta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14787	TNFAIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFAIP1	MGD	MGI:104961
Felis catus	TNFAIP1	VGNC	VGNC:66397
Rattus norvegicus	TNFAIP1	RGD	RGD:3877
Canis familiaris	TNFAIP1	VGNC	VGNC:47648
Bos taurus	TNFAIP1	VGNC	VGNC:36154
Macaca mulatta	TNFAIP1	VGNC	VGNC:78578

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