MND1 - meiotic nuclear divisions 1 Gene

Homo sapiens

Also known as GAJ

Gene ID: 84057 | Gene type: protein coding

About MND1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:153,344,649-153,415,118 (from NCBI)

This gene has 6 transcripts (splice variants) and 214 orthologues. Broad expression in testis (RPKM 3.9), lymph node (RPKM 2.6) and 15 other tissues.

Summary

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

MND1 Products(2)

mRNA	Protein	Name
NM_001253861.1	NP_001240790.1	meiotic nuclear division protein 1 homolog isoform 2
NM_032117.4	NP_115493.1	meiotic nuclear division protein 1 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16407260	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in homologous chromosome pairing at meiosis	IDA IDA: Inferred from direct assay	16407260	GOA
involved in reciprocal meiotic recombination	IDA IDA: Inferred from direct assay	16407260	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MND1 Protein Structure

Mnd1

0
100
205 a.a.

Protein Preferred Names

Protein Names

meiotic nuclear division protein 1 homolog

homolog of yeast MND1

MND1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MND1	Q9BWT6	PSMC3IP	Homo sapiens	Q9P2W1	Anti Tag CoIP	26496610
Intra	MND1	Q9BWT6	PSMC3IP	Homo sapiens	Q9P2W1	Anti Tag CoIP	33961781
Intra	MND1	Q9BWT6	PSMC3IP	Homo sapiens	Q9P2W1	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08567	MND1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MND1	VGNC	VGNC:31538
Mus musculus	MND1	MGD	MGI:1924165
Rattus norvegicus	MND1	RGD	RGD:1309007
Canis familiaris	MND1	VGNC	VGNC:43296
Felis catus	MND1	VGNC	VGNC:63542
Others	MND1	NCBI

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