HORMAD1 - HORMA domain containing 1 Gene

Homo sapiens

Also known as CT46; NOHMA

Gene ID: 84072 | Gene type: protein coding

About HORMAD1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,698,060-150,720,895 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 50.3).

Summary

This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for Cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

HORMAD1 Products(2)

mRNA	Protein	Name
NM_001199829.2	NP_001186758.1	HORMA domain-containing protein 1 isoform 2
NM_032132.5	NP_115508.2	HORMA domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HORMAD1 Protein Structure

HORMA

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

HORMA domain-containing protein 1

cancer/testis antigen 46

HORMAD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HORMAD1	Q86X24	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	HORMAD1	Q86X24	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	HORMAD1	Q86X24	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	HORMAD1	Q86X24	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HORMAD1	Q86X24	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HORMAD1	Q86X24	MYG1	Homo sapiens	Q9HB07	Y2H Array	32296183
Intra	HORMAD1	Q86X24	MYG1	Homo sapiens	Q9HB07	Y2H Prey Pooling	32296183
Intra	HORMAD1	Q86X24	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06291	HORMAD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HORMAD1	VGNC	VGNC:97775
Bos taurus	HORMAD1	VGNC	VGNC:55235
Rattus norvegicus	HORMAD1	RGD	RGD:1564960
Canis familiaris	HORMAD1	VGNC	VGNC:103682
Mus musculus	HORMAD1	MGD	MGI:1915231
Felis catus	HORMAD1	VGNC	VGNC:107556

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