1. Gene
  2. EVA1A - eva-1 homolog A, regulator of programmed cell death Gene

EVA1A - eva-1 homolog A, regulator of programmed cell death Gene

Homo sapiens

Also known as FAM176A; TMEM166

Gene ID: 84141 | Gene type: protein coding

About EVA1A

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:75,492,318-75,569,719 (from NCBI)

This gene has 11 transcripts (splice variants), 263 orthologues and 1 paralogue. Biased expression in liver (RPKM 20.6), lung (RPKM 8.7) and 7 other tissues.

Summary

Predicted to be involved in apoptotic process and Autophagy. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EVA1A Products(4)

mRNA Protein Name
NM_001135032.2 NP_001128504.1 protein eva-1 homolog A
NM_001369524.1 NP_001356453.1 protein eva-1 homolog A
NM_001369525.1 NP_001356454.1 protein eva-1 homolog A
NM_032181.3 NP_115557.1 protein eva-1 homolog A
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EVA1A Protein Structure

FAM176

FAM176: FAM176 family (13 - 152)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

protein eva-1 homolog A

family with sequence similarity 176, member A

EVA1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra EVA1A Q9H8M9 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra EVA1A Q9H8M9 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta EVA1A VGNC VGNC:106159
Mus musculus EVA1A MGD MGI:2385247
Canis familiaris EVA1A VGNC VGNC:54943
Rattus norvegicus EVA1A RGD RGD:1559797