ANXA9 - annexin A9 Gene

Homo sapiens

Also known as ANX31

Gene ID: 8416 | Gene type: protein coding

About ANXA9

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,977,306-150,995,634 (from NCBI)

This gene has 2 transcripts (splice variants), 322 orthologues and 12 paralogues. Broad expression in kidney (RPKM 12.1), thyroid (RPKM 11.7) and 23 other tissues.

Summary

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic Phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

ANXA9 Products(1)

mRNA	Protein	Name
NM_003568.3	NP_003559.2	annexin A9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine receptor activity	IDA IDA: Inferred from direct assay	10899159	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	12832069	GOA
enables phospholipid binding	IDA IDA: Inferred from direct assay	10899159	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22841549	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	10899159	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10899159	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12832069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA9 Protein Structure

Annexin

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

annexin A9

annexin 31

ANXA9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANXA9	O76027	PPL	Homo sapiens	O60437	Anti Tag CoIP	33961781
Intra	ANXA9	O76027	PPL	Homo sapiens	O60437	IF	22841549
Intra	ANXA9	O76027	PPL	Homo sapiens	O60437	Anti Bait CoIP	22841549

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pemphigus

Acantholytic Acanthoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00769	ANXA9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANXA9	VGNC	VGNC:37945
Macaca mulatta	ANXA9	VGNC	VGNC:69953
Rattus norvegicus	ANXA9	RGD	RGD:1587550
Felis catus	ANXA9	VGNC	VGNC:67714
Mus musculus	ANXA9	MGD	MGI:1923711
Bos taurus	ANXA9	VGNC	VGNC:25970

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