PPL - periplakin Gene

Homo sapiens

Gene ID: 5493 | Gene type: protein coding

About PPL

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,882,507-4,937,148 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 2 paralogues. Biased expression in esophagus (RPKM 300.0) and skin (RPKM 63.7).

Summary

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. Akt1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

PPL Products(1)

mRNA	Protein	Name
NM_002705.5	NP_002696.4	periplakin

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12244133	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19211270	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPL Protein Structure

Plectin

0
300
600
900
1200
1500
1756 a.a.

Protein Preferred Names

Protein Names

periplakin

190 kDa paraneoplastic pemphigus antigen

PPL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPL	O60437	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	PPL	O60437	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	PPL	O60437	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	PPL	O60437	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	DES	Homo sapiens	P17661	Validated Y2H	32296183
Intra	PPL	O60437	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	PPL	O60437	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	PPL	O60437	C6orf141	Homo sapiens	Q5SZD1	Y2H Array	32296183
Intra	PPL	O60437	C6orf141	Homo sapiens	Q5SZD1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	C6orf141	Homo sapiens	Q5SZD1	Validated Y2H	32296183
Intra	PPL	O60437	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	PPL	O60437	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	PPL	O60437	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	PPL	O60437	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	PPL	O60437	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	PPL	O60437	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	PPL	O60437	KCTD21	Homo sapiens	Q4G0X4	Validated Y2H	32296183
Intra	PPL	O60437	KCTD21	Homo sapiens	Q4G0X4	Y2H Prey Pooling	32296183
Intra	PPL	O60437	KCTD21	Homo sapiens	Q4G0X4	Y2H Array	32296183
Intra	PPL	O60437	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	PPL	O60437	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	PPL	O60437	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0-7	Validated Y2H	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0-7	Y2H Prey Pooling	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0-7	Y2H Array	32296183
Intra	PPL	O60437	POF1B	Homo sapiens	Q8WVV4-1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	POF1B	Homo sapiens	Q8WVV4-1	Validated Y2H	32296183
Intra	PPL	O60437	POF1B	Homo sapiens	Q8WVV4-1	Y2H Array	32296183
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4-2	Validated Y2H	32296183
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4-2	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4-2	Y2H Array	32296183
Intra	PPL	O60437	PLEKHA7	Homo sapiens	Q6IQ23-2	Y2H Prey Pooling	32296183
Intra	PPL	O60437	PLEKHA7	Homo sapiens	Q6IQ23-2	Validated Y2H	32296183
Intra	PPL	O60437	PLEKHA7	Homo sapiens	Q6IQ23-2	Y2H Array	32296183
Intra	PPL	O60437	ZNF213	Homo sapiens	O14771	Y2H Array	32296183
Intra	PPL	O60437	ZNF213	Homo sapiens	O14771	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	PPL	O60437	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZNF474	Homo sapiens	Q6S9Z5	Validated Y2H	32296183
Intra	PPL	O60437	AHCYL1	Homo sapiens	O43865	Y2H Prey Pooling	25416956
Intra	PPL	O60437	HECTD3	Homo sapiens	Q5T447	Y2H Prey Pooling	32296183
Intra	PPL	O60437	HECTD3	Homo sapiens	Q5T447	Y2H Array	32296183
Intra	PPL	O60437	HECTD3	Homo sapiens	Q5T447	Validated Y2H	32296183
Intra	PPL	O60437	AKT1	Homo sapiens	P31749	Y2H	18624398
Intra	PPL	O60437	VIM	Homo sapiens	P08670	Validated Y2H	25416956
Intra	PPL	O60437	VIM	Homo sapiens	P08670	Y2H Array	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	PPL	O60437	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	PPL	O60437	KNSTRN	Homo sapiens	Q9Y448	Y2H Array	32296183
Intra	PPL	O60437	KNSTRN	Homo sapiens	Q9Y448	Validated Y2H	32296183
Intra	PPL	O60437	KNSTRN	Homo sapiens	Q9Y448	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Array	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Validated Y2H	25416956
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Validated Y2H	32296183
Intra	PPL	O60437	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Intra	PPL	O60437	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	PPL	O60437	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PPL	O60437	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4	Validated Y2H	25416956
Intra	PPL	O60437	ZSCAN1	Homo sapiens	Q8NBB4	Y2H Prey Pooling	25416956
Intra	PPL	O60437	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	PPL	O60437	ANXA9	Homo sapiens	O76027	IF	22841549
Intra	PPL	O60437	ANXA9	Homo sapiens	O76027	Anti Tag CoIP	22841549
Intra	PPL	O60437	MRPL28	Homo sapiens	Q13084	Y2H Prey Pooling	32296183
Intra	PPL	O60437	MRPL28	Homo sapiens	Q13084	Validated Y2H	32296183
Intra	PPL	O60437	MRPL28	Homo sapiens	Q13084	Y2H Array	32296183
Intra	PPL	O60437	ZSCAN16	Homo sapiens	Q9H4T2	Validated Y2H	32296183
Intra	PPL	O60437	ZSCAN16	Homo sapiens	Q9H4T2	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZSCAN16	Homo sapiens	Q9H4T2	Y2H Array	32296183
Intra	PPL	O60437	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	25416956
Intra	PPL	O60437	ZNF165	Homo sapiens	P49910	Y2H Prey Pooling	32296183
Intra	PPL	O60437	ZNF165	Homo sapiens	P49910	Validated Y2H	32296183
Intra	PPL	O60437	ZNF165	Homo sapiens	P49910	Y2H Array	32296183
Intra	PPL	O60437	UPRT	Homo sapiens	Q96BW1	Y2H Prey Pooling	32296183
Intra	PPL	O60437	UPRT	Homo sapiens	Q96BW1	Y2H Array	32296183
Intra	PPL	O60437	UPRT	Homo sapiens	Q96BW1	Validated Y2H	32296183
Intra	PPL	O60437	ZNF263	Homo sapiens	O14978	Y2H Array	32296183
Intra	PPL	O60437	ZNF263	Homo sapiens	O14978	Y2H Prey Pooling	32296183
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0	Validated Y2H	25416956
Intra	PPL	O60437	RAB3IP	Homo sapiens	Q96QF0	Y2H Array	25416956
Intra	PPL	O60437	RALBP1	Homo sapiens	Q15311	Y2H Prey Pooling	25416956
Intra	PPL	O60437	ACTR5	Homo sapiens	Q9H9F9	Validated Y2H	32296183
Intra	PPL	O60437	ACTR5	Homo sapiens	Q9H9F9	Y2H Array	32296183
Intra	PPL	O60437	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PPL	O60437	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	PPL	O60437	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Paraneoplastic Pemphigus

Pemphigus

Pemphigus Foliaceus

Pemphigus Foliaceous	Pf
Superficial Pemphigus

Pemphigus Vulgaris, Familial

Pemphigus Vulgaris	Familial Pemphigus Vulgaris
Pemphigus

Bullous Pemphigoid

Benign Pemphigus	Senile Dermatitis Herpetiformis
Old Age Pemphigus	Parapemphigus
Pemphigoid	Pemphigoid Bullous
Pemphigoid, Bullous

Pemphigoid

Bronchiolitis Obliterans

Bronchiolitis Fibrosa Obliterans	Obliterative Bronchiolitis
Bronchiolitis Exudativa	Bronchiolitis, Exudative

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Pseudomembranous Conjunctivitis

Iga Pemphigus

Subcorneal Pustular Dermatosis

Subcorneal Pustular Dermatitis	Sneddon-Wilkinson Disease Or Syndrome
Pustulosis Subcornealis	Sneddon-Wilkinson Disease
Skin Diseases, Vesiculobullous	Vesiculobullous Skin Disease

Bullous Skin Disease

Skin Diseases Bullous

Skin Diseases, Bullous

Pemphigoid Gestationis

Herpes Gestationis	Gestational Pemphigoid
Gestational Herpes

Microcephaly And Chorioretinopathy 2

Acute Conjunctivitis

Lichen Disease

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107098	PPL-100 free acid		/	Unkown
HY-159917	PPL agonist-1		/	Unkown
HY-RS10959	PPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPL	MGD	MGI:1194898
Canis familiaris	PPL	VGNC	VGNC:44861
Rattus norvegicus	PPL	RGD	RGD:1305511
Felis catus	PPL	VGNC	VGNC:68991
Bos taurus	PPL	VGNC	VGNC:33208
Macaca mulatta	PPL	VGNC	VGNC:76240
Others	PPL	NCBI

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