SLF1 - SMC5-SMC6 complex localization factor 1 Gene

Homo sapiens

Also known as BRCTx; BRCTD1; ANKRD32

Gene ID: 84250 | Gene type: protein coding

About SLF1

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:94,618,231-94,697,621 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues and 1 paralogue. Broad expression in testis (RPKM 3.1), bone marrow (RPKM 1.1) and 23 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SLF1 Products(1)

mRNA	Protein	Name
NM_032290.4	NP_115666.2	SMC5-SMC6 complex localization factor protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25931565	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25931565	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25931565	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	25931565	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	25931565	GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	25931565	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	25931565	GOA
involved in protein localization to site of double-strand break	IDA IDA: Inferred from direct assay	25931565	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in site of double-strand break	IDA IDA: Inferred from direct assay	25931565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLF1 Protein Structure

Ank_2

Ank

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200
400
600
800
1000
1058 a.a.

Protein Preferred Names

Protein Names

SMC5-SMC6 complex localization factor protein 1

BRCT domain containing 1

SLF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLF1	Q9BQI6	SLF2	Homo sapiens	Q8IX21	Anti Tag CoIP	33961781
Intra	SLF1	Q9BQI6	SLF2	Homo sapiens	Q8IX21	Anti Tag CoIP	36373674

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Form Agnosia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129610	KB02-SLF	Inhibitor	99.25%	Unkown
HY-RS13361	SLF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLF1	MGD	MGI:2145448
Macaca mulatta	SLF1	VGNC	VGNC:84493
Bos taurus	SLF1	VGNC	VGNC:52883
Canis familiaris	SLF1	VGNC	VGNC:46502
Rattus norvegicus	SLF1	RGD	RGD:1304857
Felis catus	SLF1	VGNC	VGNC:65451

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