HAGHL - hydroxyacylglutathione hydrolase like Gene

Homo sapiens

Gene ID: 84264 | Gene type: protein coding

About HAGHL

This gene has 20 transcripts (splice variants), 159 orthologues and 4 paralogues. Broad expression in brain (RPKM 1.8), spleen (RPKM 1.6) and 20 other tissues.

Summary

Predicted to enable hydroxyacylglutathione hydrolase activity and metal ion binding activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. [provided by Alliance of Genome Resources, Apr 2022]

HAGHL Products(7)

mRNA	Protein	Name
NM_001290137.2	NP_001277066.1	hydroxyacylglutathione hydrolase-like protein isoform 2
NM_001290139.2	NP_001277068.1	hydroxyacylglutathione hydrolase-like protein isoform 2
NM_001323635.2	NP_001310564.1	hydroxyacylglutathione hydrolase-like protein isoform 2
NM_001323636.2	NP_001310565.1	hydroxyacylglutathione hydrolase-like protein isoform 3
NM_001365282.1	NP_001352211.1	hydroxyacylglutathione hydrolase-like protein isoform 4
NM_032304.4	NP_115680.1	hydroxyacylglutathione hydrolase-like protein isoform 2
NM_207112.2	NP_996995.1	hydroxyacylglutathione hydrolase-like protein isoform 1

HAGHL Protein Structure

Lactamase_B

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

hydroxyacylglutathione hydrolase-like protein

GLO2-like/ RJD12

HAGHL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAGHL	Q6PII5	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	HAGHL	Q6PII5	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	HAGHL	Q6PII5	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	HAGHL	Q6PII5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	HAGHL	Q6PII5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	HAGHL	Q6PII5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nemaline Myopathy 1

Cap Myopathy 1	NEM1
Nemaline Myopathy 1, Autosomal Dominant Or Recessive	Nemaline Myopathy, Type 1
CAPM1	Cap Disease
Cap Myopathy Tpm3-Related	Nemaline Myopathy 1 Autosomal Dominant Or Recessive
Myopathy, Nemaline, Type 1	Cap Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05993	HAGHL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HAGHL	VGNC	VGNC:73167
Rattus norvegicus	HAGHL	RGD	RGD:1308042
Bos taurus	HAGHL	VGNC	VGNC:29743
Mus musculus	HAGHL	MGD	MGI:1919877
Felis catus	HAGHL	VGNC	VGNC:62750
Canis familiaris	HAGHL	VGNC	VGNC:41586

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