NOA1 - nitric oxide associated 1 Gene

Homo sapiens

Also known as MTG3; hNOA1; C4orf14; hAtNOS1; mAtNOS1

Gene ID: 84273 | Gene type: protein coding

About NOA1

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,963,350-56,977,606 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 6 paralogues. Ubiquitous expression in colon (RPKM 10.1), duodenum (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]

NOA1 Products(1)

mRNA	Protein	Name
NM_032313.4	NP_115689.1	nitric oxide-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	19103604	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19103604	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	19103604	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with matrix side of mitochondrial inner membrane	IDA IDA: Inferred from direct assay	19103604	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOA1 Protein Structure

MMR_HSR1

0
200
400
600
698 a.a.

Protein Preferred Names

Protein Names

nitric oxide-associated protein 1

mitochondrial GTPase 3 homolog

NOA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NOA1	Q8NC60	NDUFA9	Homo sapiens	Q16795	Pull Down	19103604
Intra	NOA1	Q8NC60	NDUFA9	Homo sapiens	Q16795	Anti Bait CoIP	19103604
Intra	NOA1	Q8NC60	DAP3	Homo sapiens	P51398	Anti Bait CoIP	19103604
Intra	NOA1	Q8NC60	DAP3	Homo sapiens	P51398	Pull Down	19103604

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Sarcomatosis

Spinocerebellar Ataxia 28

Spinocerebellar Ataxia Type 28	SCA28
Ataxia, Spinocerebellar, Type 28

Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome	COFS1
Pena-Shokeir Syndrome Type 2	Cofs
Pena-Shokeir Syndrome, Type Ii	Cerebrooculofacioskeletal Syndrome
Cerebro-Oculo-Facio-Skeletal Syndrome 1	Pena Shokeir Syndrome Type 2

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09397	NOA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NOA1	VGNC	VGNC:63843
Bos taurus	NOA1	VGNC	VGNC:56755
Macaca mulatta	NOA1	VGNC	VGNC:75269
Mus musculus	NOA1	MGD	MGI:1914306
Rattus norvegicus	NOA1	RGD	RGD:1359460
Canis familiaris	NOA1	VGNC	VGNC:43871

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