PYM1 - PYM homolog 1, exon junction complex associated factor Gene

Homo sapiens

Also known as PYM; WIBG

Gene ID: 84305 | Gene type: protein coding

About PYM1

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,901,413-55,927,894 (from NCBI)

This gene has 7 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in esophagus (RPKM 16.0), colon (RPKM 12.9) and 25 other tissues.

Summary

Enables ribosome binding activity. Involved in exon-exon junction complex disassembly; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and positive regulation of translation. Located in cell junction; cytosol; and nuclear lumen. Part of exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

PYM1 Products(2)

mRNA	Protein	Name
NM_001143853.1	NP_001137325.1	partner of Y14 and mago isoform 2
NM_032345.3	NP_115721.1	partner of Y14 and mago isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16209946	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	18026120	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in exon-exon junction complex disassembly	IDA IDA: Inferred from direct assay	19410547	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	19410547	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	18026120	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	18026120	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYM1 Protein Structure

Mago-bind

0
100
204 a.a.

Protein Preferred Names

Protein Names

partner of Y14 and mago

protein wibg homolog

PYM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PYM1	Q9BRP8	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	25616068
Intra	PYM1	Q9BRP8	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	19478851
Intra	PYM1	Q9BRP8	MAGOH	Homo sapiens	P61326	Anti Bait CoIP	19410547
Intra	PYM1	Q9BRP8	MAGOH	Homo sapiens	P61326	Anti Bait CoIP	25616068
Cross	PYM1	Q9BRP8	mta_hhv8p	Human herpesvirus 8	Q2HR75	Anti Bait CoIP	20436455
Cross	PYM1	Q9BRP8	mta_hhv8p	Human herpesvirus 8	Q2HR75	Density Sedimentation	20436455
Intra	PYM1	Q9BRP8	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950
Cross	PYM1	Q9BRP8	Q99IB8-PRO_0000045592	Hepatitis C virus	Q99IB8-PRO_0000045592	Anti Bait CoIP	25616068
Cross	PYM1	Q9BRP8	Q99IB8-PRO_0000045592	Hepatitis C virus	Q99IB8-PRO_0000045592	Anti Tag CoIP	25616068

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PYM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71433	WIBG Protein, Human (His)	Q9BRP8 (M1-L204)	≥95%

Related Diseases

Diseases

Alias

Palmoplantar Keratoderma, Punctate Type Ia

Keratosis Palmoplantaris Papulosa	Punctate Palmoplantar Keratoderma Type I
Ppkp1	Keratodermia Palmoplantaris Papulosa, Buschke-Fischer-Brauer Type
PPKP1A	Kppp1
Punctate Palmoplantar Keratoderma Type 1	Palmoplantar Keratoderma, Punctate Type 1a
Palmoplantar Keratoderma, Punctate Type I	Keratoderma, Palmoplantar, Punctate Type Ia
Punctate Palmoplantar Keratoderma Type 1a	Punctate Palmoplantar Keratoderma Type 1b
Brauer-Buschke-Fischer Syndrome	Keratoderma, Palmoplantar Punctate Type 1
Type I Punctate Palmoplantar Keratoderma	Buschke-Fischer-Brauer Syndrome
Keratoderma, Palmoplantar, Punctate 1a	Keratodermia Palmoplantaris Papulosa Buschke-Fischer-Brauer Type
Keratosis Punctate Palmoplantaris Buschke-Fisher-Brauer Type	Punctate Palmoplantar Keratoderma Type Ia
Keratoderma, Palmoplantar, Punctate Type 1	Keratoderma, Palmoplantar, Punctate, Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11494	PYM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PYM1	VGNC	VGNC:76570
Felis catus	PYM1	VGNC	VGNC:64453
Canis familiaris	PYM1	VGNC	VGNC:45228
Bos taurus	PYM1	VGNC	VGNC:33592
Rattus norvegicus	PYM1	RGD	RGD:1306096
Mus musculus	PYM1	MGD	MGI:1925678

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