Sfrp1 - secreted frizzled-related protein 1 Gene

Rattus norvegicus

Also known as sFRP-1

Gene ID: 84402 | Gene type: protein coding

About Sfrp1

Primary_assembly 16: 68,575,763-68,614,286 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 223 orthologues, 15 paralogues and is associated with 10 phenotypes. Biased expression in Kidney (RPKM 136.3), Spleen (RPKM 19.3) and 9 other tissues.

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of osteoclast differentiation; and osteoblast differentiation. Predicted to be located in cell surface; collagen-containing extracellular matrix; and cytosol. Predicted to be active in extracellular space. Orthologous to human SFRP1 (secreted Frizzled related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp1 Products(1)

mRNA	Protein	Name
NM_001276712.2	NP_001263641.2	secreted frizzled-related protein 1 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	16149051	RGD
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16149051	RGD
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16149051	RGD
involved in negative regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	17540629	RGD
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	16149051	RGD
involved in regulation of ossification	IMP IMP: Inferred from mutant phenotype	15677765	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sfrp1 Protein Structure

CRD_SFRP1

NTR_Sfrp1_like

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

secreted frizzled-related protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10858	WAY 316606	Inhibitor	99.24%	Unkown
HY-10858A	WAY 316606 hydrochloride	Inhibitor	/	Unkown
HY-RS12772	SFRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12773	Sfrp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12774	Sfrp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sfrp1	NCBI	NCBI:6422
Mus musculus	Sfrp1	NCBI	NCBI:20377

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