NEURL4 - neuralized E3 ubiquitin protein ligase 4 Gene

Homo sapiens

Gene ID: 84461 | Gene type: protein coding

About NEURL4

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,315,628-7,329,335 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 182 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.0) and 25 other tissues.

Summary

The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

NEURL4 Products(2)

mRNA	Protein	Name
NM_001005408.2	NP_001005408.1	neuralized-like protein 4 isoform 2
NM_032442.3	NP_115818.2	neuralized-like protein 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22441691	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEURL4 Protein Structure

Neuralized

0
300
600
900
1200
1562 a.a.

Protein Preferred Names

Protein Names

neuralized-like protein 4

neuralized homolog 4

NEURL4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEURL4	Q96JN8	CCP110	Homo sapiens	O43303	Pull Down	22441691
Intra	NEURL4	Q96JN8	CCP110	Homo sapiens	O43303	Anti Bait CoIP	22441691

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 75

RP75	Retinitis Pigmentosa, Type 75

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Dyschromatosis Universalis Hereditaria

Duh

Atrophic Rhinitis

Rhinitis, Atrophic	Ozena
Rhinitis Sicca	Dry Rhinitis
Ozaena

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09223	NEURL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NEURL4	VGNC	VGNC:54462
Macaca mulatta	NEURL4	VGNC	VGNC:82197
Mus musculus	NEURL4	MGD	MGI:1921092
Rattus norvegicus	NEURL4	RGD	RGD:1308056
Felis catus	NEURL4	VGNC	VGNC:99289

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