Cxcr3 - C-X-C motif chemokine receptor 3 Gene

Rattus norvegicus

Also known as Gpr9

Gene ID: 84475 | Gene type: protein coding

About Cxcr3

Primary_assembly X: 66,844,318-66,846,969 reverse strand.mRatBN7.2:CM026994.1

This gene has 2 transcripts (splice variants), 289 orthologues, 24 paralogues and is associated with 47 phenotypes. Biased expression in Spleen (RPKM 53.), Thymus (RPKM 34.7) and 7 other tissues.

Summary

Enables C-X-C Chemokine Receptor activity. Involved in T cell chemotaxis; calcium-mediated signaling; and positive regulation of cytosolic calcium ion concentration. Located in external side of plasma membrane. Used to study dilated cardiomyopathy; high grade glioma; myocarditis; and renovascular hypertension. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr3 Products(1)

mRNA	Protein	Name
NM_053415.1	NP_445867.1	C-X-C chemokine receptor type 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-X-C chemokine receptor activity	IPI IPI: Inferred from physical interaction	10825390	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	21038468	RGD
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	10825390	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10825390	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16434036	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr3 Protein Structure

7tmA_CXCR3

0
100
200
300
367 a.a.

Protein Preferred Names

Protein Names

C-X-C chemokine receptor type 3

CXC-R3	CXCR-3
G protein-coupled receptor 9	IP-10 receptor
chemokine (C-X-C motif) receptor 3	interferon-inducible protein 10 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15319	AMG 487	Inhibitor	99.65%	Unkown
HY-13406	TAK-779	Antagonist	99.73%	Unkown
HY-10017	SCH 546738	Antagonist	98.71%	Unkown
HY-15320	NBI-74330	Antagonist	98.57%	Unkown
HY-149055	ACT-777991	Antagonist	99.86%	Unkown
HY-111149A	PS372424 hydrochloride	Agonist	≥98.0%	Unkown
HY-151096	ACT-660602	Antagonist	99.86%	Unkown
HY-15319B	AMG 487 (S-enantiomer)	Antagonist	99.94%	Unkown
HY-111149	PS372424	Agonist	/	Unkown
HY-128063	CXCR3 antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cxcr3	NCBI	NCBI:2833

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