AMG 487 (S-enantiomer)

Name: AMG 487 (S-enantiomer)
Brand: MedChemExpress
SKU: HY-15319B
Rating: 4.5 (1 reviews)

Cat. No.: HY-15319B Purity: 99.94%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3.

For research use only. We do not sell to patients.

AMG 487 (S-enantiomer) Chemical Structure

CAS No. : 473720-30-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 120	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 120	In-stock	Estimated Time of Arrival: December 31
Solid
2 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 144	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 770	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of AMG 487 (S-enantiomer):

AMG 487 In-stock
(±)-AMG 487 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor CXCR3.

IC₅₀ & Target^[1]

CXCR3

In Vitro

AMG 487 S-enantiomer (Compound 3.74) is the S enantiomer of AMG 487^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

603.59

Formula

C₃₂H₂₈F₃N₅O₄

CAS No.

473720-30-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N([C@@H](C)C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (165.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6568 mL	8.2838 mL	16.5675 mL
5 mM	0.3314 mL	1.6568 mL	3.3135 mL
10 mM	0.1657 mL	0.8284 mL	1.6568 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 7.5 mg/mL (12.43 mM); Clear solution

This protocol yields a clear solution of ≥ 7.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (75.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.94%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (253 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. CXCR3 ANTAGONISTS. WIPO Patent Application WO/2002/083143

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6568 mL	8.2838 mL	16.5675 mL	41.4188 mL
	5 mM	0.3314 mL	1.6568 mL	3.3135 mL	8.2838 mL
	10 mM	0.1657 mL	0.8284 mL	1.6568 mL	4.1419 mL
	15 mM	0.1105 mL	0.5523 mL	1.1045 mL	2.7613 mL
	20 mM	0.0828 mL	0.4142 mL	0.8284 mL	2.0709 mL
	25 mM	0.0663 mL	0.3314 mL	0.6627 mL	1.6568 mL
	30 mM	0.0552 mL	0.2761 mL	0.5523 mL	1.3806 mL
	40 mM	0.0414 mL	0.2071 mL	0.4142 mL	1.0355 mL
	50 mM	0.0331 mL	0.1657 mL	0.3314 mL	0.8284 mL
	60 mM	0.0276 mL	0.1381 mL	0.2761 mL	0.6903 mL
	80 mM	0.0207 mL	0.1035 mL	0.2071 mL	0.5177 mL
	100 mM	0.0166 mL	0.0828 mL	0.1657 mL	0.4142 mL