TTF2 - transcription termination factor 2 Gene

Homo sapiens

Also known as F2; HuF2; ZGRF6

Gene ID: 8458 | Gene type: protein coding

About TTF2

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,060,326-117,107,453 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues and 30 paralogues. Ubiquitous expression in lymph node (RPKM 3.1), appendix (RPKM 2.5) and 25 other tissues.

Summary

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

TTF2 Products(1)

mRNA	Protein	Name
NM_003594.4	NP_003585.3	transcription termination factor 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	9748214	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12927788	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTF2 Protein Structure

zf-GRF

SNF2_N

Helicase_C

0
200
400
600
800
1000
1162 a.a.

Protein Preferred Names

Protein Names

transcription termination factor 2

RNA polymerase II termination factor

TTF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TTF2	Q9UNY4	CDC5L	Homo sapiens	Q99459	Anti Bait CoIP	12927788
Intra	TTF2	Q9UNY4	CDC5L	Homo sapiens	Q99459	Chromatography	12927788

Cross: Cross-species interaction Intra: Intraspecies interaction

TTF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82558	Transcription Termination Factor 2 Antibody (YA2303)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat

Related Diseases

Diseases

Alias

Sexual Sadism

Sadism

Narcissistic Personality Disorder

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Antisocial Personality Disorder

Dissocial Personality Disorder	Asocial Personality
Psychopath.Personality	Psychopathic Personality
Psychopathic Personality Disorder	Sociopathic Personality

Brunner Syndrome

Monoamine Oxidase A Deficiency	Antisocial Behavior
BRNRS	Deficiency Of Monoamine Oxidase A
X-Linked Monoamine Oxidase Deficiency	Susceptibility To Antisocial Behavior
Antisocial Behavior, Susceptibility To	Anti-Social Behavior

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Resting Heart Rate, Variation In

Resting Heart Rate	Rhr
Resting Heart Rate, Variation

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15223	TTF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TTF2	VGNC	VGNC:82263
Rattus norvegicus	TTF2	RGD	RGD:1309145
Canis familiaris	TTF2	VGNC	VGNC:47968
Mus musculus	TTF2	MGD	MGI:1921294
Bos taurus	TTF2	VGNC	VGNC:36484
Felis catus	TTF2	VGNC	VGNC:66680

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