CDC5L - cell division cycle 5 like Gene

Homo sapiens

Also known as CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1

Gene ID: 988 | Gene type: protein coding

About CDC5L

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,387,706-44,450,425 (from NCBI)

Ubiquitous expression in testis (RPKM 9.6), bone marrow (RPKM 8.1) and 25 other tissues.

Summary

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

CDC5L Products(1)

mRNA	Protein	Name
NM_001253.4	NP_001244.1	cell division cycle 5-like protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11082045	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11082045	GOA
enables WD40-repeat domain binding	IDA IDA: Inferred from direct assay	20176811	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20176811	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12927788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	24332808	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11082045	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of DNA replication factor A complex	IDA IDA: Inferred from direct assay	24332808	GOA
part of Prp19 complex	IDA IDA: Inferred from direct assay	20176811	GOA
part of Prp19 complex	IPI IPI: Inferred from physical interaction	20176811	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9038199	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	16332694	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20176811	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	20176811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC5L Protein Structure

Myb_DNA-bind_6

Myb_Cef

0
200
400
600
802 a.a.

Protein Preferred Names

Protein Names

cell division cycle 5-like protein

CDC5 cell division cycle 5-like

CDC5L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC5L	Q99459	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	CDC5L	Q99459	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	CDC5L	Q99459	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Prey Pooling	25416956
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Crosslink	20176811
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Solution Sedimentation	20176811
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Comigration in SDS	20176811
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Enzymatic Footprint	20176811
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	EM	20176811
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Far-WB	20176811
Intra	CDC5L	Q99459	BCAS2	Homo sapiens	O75934	Density Sedimentation	20176811
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	Comigration in SDS	20176811
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	Density Sedimentation	20176811
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	EM	20176811
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	Solution Sedimentation	20176811
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	FRET	20467437
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	PLRG1	Homo sapiens	O43660	Enzymatic Footprint	20176811
Intra	CDC5L	Q99459	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	CDC5L	Q99459	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Fragment Pooling	31413325
Intra	CDC5L	Q99459	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CDC5L	Q99459	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	CDC5L	Q99459	TTF2	Homo sapiens	Q9UNY4	Y2H	12927788
Intra	CDC5L	Q99459	SF3A2	Homo sapiens	Q15428	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	CDC5L	Q99459	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	CDC5L	Q99459	SPTBN1	Homo sapiens	Q01082	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	SPTBN1	Homo sapiens	Q01082	Y2H Fragment Pooling	31413325
Intra	CDC5L	Q99459	SYNPO	Homo sapiens	Q8N3V7	Y2H Array	32296183
Intra	CDC5L	Q99459	SYNPO	Homo sapiens	Q8N3V7	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	HNRNPC	Homo sapiens	P07910	Crosslink	30021884
Intra	CDC5L	Q99459	HNRNPC	Homo sapiens	P07910	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	TXLNA	Homo sapiens	P40222	Y2H Array	32296183
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	EM	20176811
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	Density Sedimentation	20176811
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	Solution Sedimentation	20176811
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	Enzymatic Footprint	20176811
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	Far-WB	20176811
Intra	CDC5L	Q99459	PRPF19	Homo sapiens	Q9UMS4	Comigration in SDS	20176811
Intra	CDC5L	Q99459	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	HNRNPM	Homo sapiens	P52272	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	HNRNPM	Homo sapiens	P52272	FRET	20467437
Intra	CDC5L	Q99459	HNRNPM	Homo sapiens	P52272	Pull Down	20467437
Intra	CDC5L	Q99459	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	CDC5L	Q99459	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	CDC5L	Q99459	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CDC5L	Q99459	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CDC5L	Q99459	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	KDM1A	Homo sapiens	O60341	Y2H Fragment Pooling	31413325
Intra	CDC5L	Q99459	KDM1A	Homo sapiens	O60341	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	CDC5L	Q99459	KANSL1	Homo sapiens	Q7Z3B3	Anti Bait CoIP	20467437
Intra	CDC5L	Q99459	KANSL1	Homo sapiens	Q7Z3B3	Y2H Fragment Pooling	31413325
Intra	CDC5L	Q99459	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	CDC5L	Q99459	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	HOOK1	Homo sapiens	Q9UJC3	Validated Y2H	32296183
Intra	CDC5L	Q99459	HOOK1	Homo sapiens	Q9UJC3	Y2H Array	32296183
Intra	CDC5L	Q99459	HOOK1	Homo sapiens	Q9UJC3	Y2H Prey Pooling	32296183
Intra	CDC5L	Q99459	HOOK1	Homo sapiens	Q9UJC3	Y2H Fragment Pooling	31413325
Intra	CDC5L	Q99459	CTNNBL1	Homo sapiens	Q8WYA6	Comigration in SDS	20176811
Intra	CDC5L	Q99459	CTNNBL1	Homo sapiens	Q8WYA6	EM	20176811
Intra	CDC5L	Q99459	CTNNBL1	Homo sapiens	Q8WYA6	Far-WB	20176811
Intra	CDC5L	Q99459	CTNNBL1	Homo sapiens	Q8WYA6	Solution Sedimentation	20176811
Intra	CDC5L	Q99459	CTNNBL1	Homo sapiens	Q8WYA6	Enzymatic Footprint	20176811
Intra	CDC5L	Q99459	ATR	Homo sapiens	Q13535	Anti Bait CoIP	19633697

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC5L Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83415	CDC5 Antibody (YA3160)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Renal Dysplasia

Kidney Dysplasia	Renal Cell Dysplasia
Congenital Renal Dysplasia	Dysplasia Of Kidney
Dysplastic Kidney

Poikiloderma With Neutropenia

Poikiloderma With Neutropenia, Clericuzio Type	PN
Clericuzio Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia, Clericuzio-Type
Clericuzio-Type Poikiloderma With Neutropenia	Poikiloderma With Neutropenia Clericuzio Type
Immune-Deficient Poikiloderma	Clericuzio-Type Poikiloderma Neutropenia Syndrome
Poikiloderma With Neutropenia Clericuzio-Type	Poikiloderma, With Neutropenia

Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic	Familial Hepatic Adenoma
Familial Liver Cell Adenomas	Liver Cell Adenomas, Familial
Hepatic Adenomas Familial	HEPAF
Ha	Hepatocellular Adenomas
Hepatocellular Adenoma

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15339	CVT-313	Inhibitor	99.90%	Unkown
HY-RS02307	CDC5L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDC5L	MGD	MGI:1918952
Bos taurus	CDC5L	VGNC	VGNC:27080
Felis catus	CDC5L	VGNC	VGNC:60663
Rattus norvegicus	CDC5L	RGD	RGD:70892
Macaca mulatta	CDC5L	VGNC	VGNC:70801
Canis familiaris	CDC5L	VGNC	VGNC:39008

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