2. Gene
  3. CARD6 - caspase recruitment domain family member 6 Gene

CARD6 - caspase recruitment domain family member 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CINCIN1

Gene ID: 84674 | Gene type: protein coding

About CARD6

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,841,367-40,855,354 (from NCBI)

This gene has 2 transcripts (splice variants), 84 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 6.9), spleen (RPKM 6.3) and 24 other tissues.

Summary

This gene encodes a protein that contains a Caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]

CARD6 Products(1)

mRNA Protein Name
NM_032587.4 NP_115976.2 caspase recruitment domain-containing protein 6

CARD6 Protein Structure

CARD

CARD: Caspase recruitment domain (9 - 89)

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  • 1037 a.a.
Protein Preferred Names Protein Names

caspase recruitment domain-containing protein 6

CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activation

Related Diseases

Diseases Alias
Glioblastoma Mesenchymal Subtype
Inflammatory Bowel Disease 3

IBD3
Inflammatory Bowel Disease 6

IBD6
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01921 CARD6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CARD6 VGNC VGNC:38717
Mus musculus CARD6 MGD MGI:3032959
Macaca mulatta CARD6 VGNC VGNC:70569
Rattus norvegicus CARD6 RGD RGD:1305805
Bos taurus CARD6 VGNC VGNC:26763
Felis catus CARD6 VGNC VGNC:60367