PPP1R9B - protein phosphatase 1 regulatory subunit 9B Gene

Homo sapiens

Also known as Spn; SPINO; PPP1R6; PPP1R9

Gene ID: 84687 | Gene type: protein coding

About PPP1R9B

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,133,737-50,150,677 (from NCBI)

This gene has 2 transcripts (splice variants), 272 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 26.2), spleen (RPKM 25.4) and 24 other tissues.

Summary

This gene encodes a scaffold protein that functions as a regulatory subunit of protein Phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

PPP1R9B Products(1)

mRNA	Protein	Name
NM_032595.5	NP_115984.3	neurabin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11278317	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	19151759	GOA
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	19151759	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	11278317	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11278317	GOA
located in filopodium	IDA IDA: Inferred from direct assay	19151759	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	19151759	GOA
located in nucleoplasm	IMP IMP: Inferred from mutant phenotype	11278317	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19151759	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19151759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R9B Protein Structure

PDZ

0
200
400
600
815 a.a.

Protein Preferred Names

Protein Names

neurabin-2

neurabin-II

PPP1R9B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R9B	Q96SB3	PPP1CB	Homo sapiens	P62140	Anti Bait CoIP	25785436

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Limbic Encephalitis

Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2	CPVT2
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Ventricular Tachycardia, Stress-Induced Polymorphic
Cvpt2	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation

Aspirin Allergy

Acetylsalicylic Acid Allergy

Asa Allergy

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11006	PPP1R9B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP1R9B	RGD	RGD:632281
Mus musculus	PPP1R9B	MGD	MGI:2387581
Canis familiaris	PPP1R9B	VGNC	VGNC:44903
Bos taurus	PPP1R9B	VGNC	VGNC:106876
Felis catus	PPP1R9B	VGNC	VGNC:69006
Macaca mulatta	PPP1R9B	VGNC	VGNC:76372

Name
Email *

	Sorry, but the email address you supplied was invalid.