LRCH3 - leucine rich repeats and calponin homology domain containing 3 Gene

Homo sapiens

Gene ID: 84859 | Gene type: protein coding

About LRCH3

This gene has 19 transcripts (splice variants), 199 orthologues and 31 paralogues. Ubiquitous expression in ovary (RPKM 3.8), lymph node (RPKM 3.6) and 25 other tissues.

Summary

Involved in septin Cytoskeleton organization. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LRCH3 Products(7)

mRNA	Protein	Name
NM_001363887.1	NP_001350816.1	DISP complex protein LRCH3 isoform 1
NM_001365715.1	NP_001352644.1	DISP complex protein LRCH3 isoform 3
NM_001365716.1	NP_001352645.1	DISP complex protein LRCH3 isoform 4
NM_001365717.1	NP_001352646.1	DISP complex protein LRCH3 isoform 5
NM_001365718.1	NP_001352647.1	DISP complex protein LRCH3 isoform 6
NM_001365719.2	NP_001352648.1	DISP complex protein LRCH3 isoform 7
NM_032773.4	NP_116162.1	DISP complex protein LRCH3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24255178	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in septin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	29467281	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRCH3 Protein Structure

LRR_1

LRR_8

0
200
400
600
777 a.a.

Protein Preferred Names

Protein Names

DISP complex protein LRCH3

leucine-rich repeat and calponin homology domain-containing protein 3

LRCH3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LRCH3	Q96II8	DOCK8	Homo sapiens	Q8NF50-2	Y2H Prey Pooling	25416956
Intra	LRCH3	Q96II8	DOCK8	Homo sapiens	Q8NF50-2	Validated Y2H	25416956
Intra	LRCH3	Q96II8	DOCK8	Homo sapiens	Q8NF50-2	Y2H Array	25416956
Intra	LRCH3	Q96II8	MYO6	Homo sapiens	Q9UM54-1	Y2H	29467281
Intra	LRCH3	Q96II8	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	33961781
Intra	LRCH3	Q96II8	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	24255178
Intra	LRCH3	Q96II8	DOCK7	Homo sapiens	Q96N67	Anti Tag CoIP	29467281
Intra	LRCH3	Q96II8	DOCK7	Homo sapiens	Q96N67	IF	29467281
Intra	LRCH3	Q96II8	MYO6	Homo sapiens	Q9UM54	Anti Tag CoIP	29467281
Intra	LRCH3	Q96II8	MYO6	Homo sapiens	Q9UM54	BioID	29467281

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 2

Hypertrophic Cardiomyopathy 2	CMH2
Cardiomyopathy, Hypertrophic, 2	Cardiomyopathy Familial Hypertrophic 2
Cardiomyopathy, Familial Hypertrophic 2	Cardiomyopathy, Hypertrophic, Familial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07779	LRCH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRCH3	RGD	RGD:1306200
Mus musculus	LRCH3	MGD	MGI:1917394
Felis catus	LRCH3	VGNC	VGNC:63274
Bos taurus	LRCH3	VGNC	VGNC:30973
Macaca mulatta	LRCH3	VGNC	VGNC:74382
Canis familiaris	LRCH3	VGNC	VGNC:53078

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