KLHL22 - kelch like family member 22 Gene

Homo sapiens

Also known as KELCHL

Gene ID: 84861 | Gene type: protein coding

About KLHL22

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,441,519-20,495,795 (from NCBI)

This gene has 12 transcripts (splice variants), 194 orthologues and 54 paralogues. Ubiquitous expression in brain (RPKM 3.8), thyroid (RPKM 3.7) and 25 other tissues.

Summary

Enables 14-3-3 protein binding activity. Involved in several processes, including cellular protein metabolic process; cellular response to leucine; and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including cytosol; intercellular bridge; and microtubule Cytoskeleton. Part of Cul3-RING ubiquitin Ligase complex. Colocalizes with lysosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

KLHL22 Products(1)

mRNA	Protein	Name
NM_032775.4	NP_116164.2	kelch-like protein 22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	29769719	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23455478	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29769719	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell division	IMP IMP: Inferred from mutant phenotype	19995937	GOA
involved in cellular response to L-leucine	IMP IMP: Inferred from mutant phenotype	29769719	GOA
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	29769719	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	23455478	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	23455478	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	29769719	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	36394357	GOA
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	33109719	GOA
involved in positive regulation of T cell mediated immune response to tumor cell	IDA IDA: Inferred from direct assay	33109719	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	29769719	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	29769719	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	29769719	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	29769719	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	29769719	GOA
involved in protein monoubiquitination	IDA IDA: Inferred from direct assay	23455478	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	36394357	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19995937	GOA
located in centrosome	IDA IDA: Inferred from direct assay	23455478	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23455478	GOA
located in cytosol	IDA IDA: Inferred from direct assay	29769719	GOA
colocalizes with lysosome	IDA IDA: Inferred from direct assay	29769719	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	23455478	GOA
colocalizes with nucleus	IDA IDA: Inferred from direct assay	29769719	GOA
located in polar microtubule	IDA IDA: Inferred from direct assay	23455478	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL22 Protein Structure

BTB

BACK

Kelch_6

Kelch_1

Kelch_3

Kelch_1

0
100
200
300
400
500
634 a.a.

Protein Preferred Names

Protein Names

kelch-like protein 22

kelch-like 22

KLHL22 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLHL22	Q53GT1	TARDBP	Homo sapiens	Q13148	Anti Tag CoIP	37788672
Intra	KLHL22	Q53GT1	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	33961781
Intra	KLHL22	Q53GT1	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	28514442
Intra	KLHL22	Q53GT1	NUDCD3	Homo sapiens	Q8IVD9	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mixed Fibrolamellar Hepatocellular Carcinoma

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07363	KLHL22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLHL22	RGD	RGD:1306288
Bos taurus	KLHL22	VGNC	VGNC:30651
Felis catus	KLHL22	VGNC	VGNC:82548
Mus musculus	KLHL22	MGD	MGI:1337995
Canis familiaris	KLHL22	VGNC	VGNC:42457

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