NUDCD3 - NudC domain containing 3 Gene

Homo sapiens

Also known as NudCL

Gene ID: 23386 | Gene type: protein coding

About NUDCD3

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,379,119-44,490,658 (from NCBI)

This gene has 11 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 28.0), ovary (RPKM 14.4) and 25 other tissues.

Summary

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]

NUDCD3 Products(1)

mRNA	Protein	Name
NM_015332.4	NP_056147.2	nudC domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16754861	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	25205765	GOA
involved in protein localization to pericentriolar material	IMP IMP: Inferred from mutant phenotype	25205765	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	25205765	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDCD3 Protein Structure

Nudc_N

0
100
200
300
361 a.a.

Protein Preferred Names

Protein Names

nudC domain-containing protein 3

NudC-like protein

NUDCD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUDCD3	Q8IVD9	KLHL15	Homo sapiens	Q96M94	Lumier	25036637
Intra	NUDCD3	Q8IVD9	KLHL23	Homo sapiens	Q8NBE8	Anti Tag CoIP	25036637
Intra	NUDCD3	Q8IVD9	KLHDC10	Homo sapiens	Q6PID8	Lumier	25036637
Intra	NUDCD3	Q8IVD9	SF3B3	Homo sapiens	Q15393	Anti Tag CoIP	25036637
Intra	NUDCD3	Q8IVD9	SF3B3	Homo sapiens	Q15393	Lumier	25036637
Intra	NUDCD3	Q8IVD9	KLHL6	Homo sapiens	Q8WZ60	Lumier	25036637
Intra	NUDCD3	Q8IVD9	PAFAH1B1	Homo sapiens	P43034	Pull Down	16754861
Intra	NUDCD3	Q8IVD9	PAFAH1B1	Homo sapiens	P43034	Anti Tag CoIP	16754861
Intra	NUDCD3	Q8IVD9	GAN	Homo sapiens	Q9H2C0	Lumier	25036637
Intra	NUDCD3	Q8IVD9	RADX	Homo sapiens	Q6NSI4	Anti Tag CoIP	25036637
Intra	NUDCD3	Q8IVD9	RADX	Homo sapiens	Q6NSI4	Lumier	25036637
Intra	NUDCD3	Q8IVD9	KLHDC8A	Homo sapiens	Q8IYD2	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09660	NUDCD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUDCD3	VGNC	VGNC:75447
Bos taurus	NUDCD3	VGNC	VGNC:32324
Mus musculus	NUDCD3	MGD	MGI:2144158
Felis catus	NUDCD3	VGNC	VGNC:63911
Rattus norvegicus	NUDCD3	RGD	RGD:1642416

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