RIOX2 - ribosomal oxygenase 2 Gene

Homo sapiens

Also known as ROX; MDIG; MINA; NO52; JMJD10; MINA53

Gene ID: 84864 | Gene type: protein coding

About RIOX2

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:97,941,818-97,972,431 (from NCBI)

This gene has 9 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 23.6), skin (RPKM 10.0) and 24 other tissues.

Summary

MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

RIOX2 Products(4)

mRNA	Protein	Name
NM_001042533.3	NP_001035998.1	ribosomal oxygenase 2 isoform a
NM_001261829.2	NP_001248758.1	ribosomal oxygenase 2 isoform b
NM_032778.6	NP_116167.3	ribosomal oxygenase 2 isoform b
NM_153182.4	NP_694822.2	ribosomal oxygenase 2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables peptidyl-histidine dioxygenase activity	EXP EXP: Inferred from Experiment	23103944	GOA
enables peptidyl-histidine dioxygenase activity	IDA IDA: Inferred from direct assay	23103944	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIOX2 Protein Structure

Cupin_4

0
100
200
300
400
465 a.a.

Protein Preferred Names

Protein Names

ribosomal oxygenase 2

60S ribosomal protein L27a histidine hydroxylase

RIOX2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RIOX2	Q8IUF8	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	RIOX2	Q8IUF8	tax	Human T-cell leukemia virus	P03410	Y2H Array	22458338
Intra	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Prey Pooling	32296183
Intra	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Validated Y2H	32296183
Intra	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Array	25416956
Intra	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Array	32296183
Intra	RIOX2	Q8IUF8	RIOX2	Homo sapiens	Q8IUF8	Y2H Pooling	16189514
Intra	RIOX2	Q8IUF8	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338
Intra	RIOX2	Q8IUF8	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11991	RIOX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RIOX2	VGNC	VGNC:45593
Rattus norvegicus	RIOX2	RGD	RGD:708521
Macaca mulatta	RIOX2	VGNC	VGNC:76777
Felis catus	RIOX2	VGNC	VGNC:64639
Bos taurus	RIOX2	VGNC	VGNC:33980
Mus musculus	RIOX2	MGD	MGI:1914264

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