AIFM2 - apoptosis inducing factor mitochondria associated 2 Gene

Homo sapiens

Also known as AMID; FSP1; PRG3

Gene ID: 84883 | Gene type: protein coding

About AIFM2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,112,271-70,132,825 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Broad expression in fat (RPKM 26.6), thyroid (RPKM 7.3) and 22 other tissues.

Summary

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to Apoptosis in the presence of Bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon Cancer cells. [provided by RefSeq, Nov 2010]

AIFM2 Products(2)

mRNA	Protein	Name
NM_001198696.2	NP_001185625.1	ferroptosis suppressor protein 1
NM_032797.6	NP_116186.1	ferroptosis suppressor protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15958387	GOA
enables electron-transferring-flavoprotein dehydrogenase activity	IDA IDA: Inferred from direct assay	15958387	GOA
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	15958387	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	31634899	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	11980907	GOA
involved in cellular detoxification	IDA IDA: Inferred from direct assay	35922516	GOA
involved in negative regulation of ferroptosis	IDA IDA: Inferred from direct assay	35922516	GOA
involved in negative regulation of ferroptosis	IMP IMP: Inferred from mutant phenotype	31634899	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	11980907	GOA
involved in ubiquinone metabolic process	IDA IDA: Inferred from direct assay	31634899	GOA
involved in vitamin K metabolic process	IDA IDA: Inferred from direct assay	35922516	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12135761	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11980907	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	11980907	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	11980907	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	31634900	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIFM2 Protein Structure

Pyr_redox_2

Pyr_redox

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

ferroptosis suppressor protein 1

apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136057	iFSP1	Activator	99.96%	Unkown
HY-RS00493	AIFM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-157744	Coumarin–quinone conjugate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AIFM2	VGNC	VGNC:37738
Rattus norvegicus	AIFM2	RGD	RGD:1304964
Macaca mulatta	AIFM2	VGNC	VGNC:69666
Mus musculus	AIFM2	MGD	MGI:1918611
Bos taurus	AIFM2	VGNC	VGNC:25762
Felis catus	AIFM2	VGNC	VGNC:59700
Others	AIFM2	NCBI

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