LINGO1 - leucine rich repeat and Ig domain containing 1 Gene

Homo sapiens

Also known as LERN1; MRT64; LRRN6A; UNQ201

Gene ID: 84894 | Gene type: protein coding

About LINGO1

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,613,027-77,820,900 (from NCBI)

This gene has 14 transcripts (splice variants), 261 orthologues, 25 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 24.2), placenta (RPKM 1.9) and 3 other tissues.

Summary

Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]

LINGO1 Products(12)

mRNA	Protein	Name
NM_001301186.2	NP_001288115.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301187.2	NP_001288116.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301189.2	NP_001288118.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301191.2	NP_001288120.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301192.2	NP_001288121.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301194.2	NP_001288123.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301195.2	NP_001288124.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301197.2	NP_001288126.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301198.2	NP_001288127.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301199.2	NP_001288128.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301200.2	NP_001288129.1	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_032808.7	NP_116197.4	leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14966521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LINGO1 Protein Structure

LRR_8

LRR_1

LRR_8

I-set

0
100
200
300
400
500
620 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

leucine rich repeat neuronal 6A

LINGO1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LINGO1	Q96FE5	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	LINGO1	Q96FE5	NTM	Homo sapiens	Q9P121-3	Validated Y2H	32296183
Intra	LINGO1	Q96FE5	NGFR	Homo sapiens	P08138	Anti Tag CoIP	20659559
Intra	LINGO1	Q96FE5	MACO1	Homo sapiens	Q8N5G2	Y2H Array	32296183
Intra	LINGO1	Q96FE5	EGFR	Homo sapiens	P00533	Anti Bait CoIP	17726113
Intra	LINGO1	Q96FE5	APP	Homo sapiens	P05067-4	Anti Bait CoIP	22133804
Intra	LINGO1	Q96FE5	APP	Homo sapiens	P05067-4	Anti Tag CoIP	22133804
Intra	LINGO1	Q96FE5	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	LINGO1	Q96FE5	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	25416956
Intra	LINGO1	Q96FE5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	LINGO1	Q96FE5	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	LINGO1	Q96FE5	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	LINGO1	Q96FE5	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	LINGO1	Q96FE5	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Cross	LINGO1	Q96FE5	Rtn4r	Rattus norvegicus	Q99M75	ELISA	14966521

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 64

MRT64	Mental Retardation, Autosomal Recessive 64
Autosomal Recessive Intellectual Developmental Disorder 64	Mental Retardation, Autosomal Recessive, Type 64

Essential Tremor

Benign Essential Tremor	Familial Tremor
Hereditary Essential Tremor	Essential Hereditary Tremor
Shaky Hand Syndrome	Benign Essential Tremor Syndrome
Tremor Hereditary Essential	Essential Tremor, Susceptibility To
Tremor, Hereditary Essential

Tremor, Hereditary Essential, 1

ETM1	Fet1
Essential Tremor 1	Tremor, Familial Essential, 1
Essential Tremor, Hereditary, 1	Hereditary Essential Tremor 1
Tremor Hereditary Essential, 1	Tremor Familial Essential, 1
Tremor, Hereditary Essential 1	Tremor, Essential Hereditary, Type 1

Syndromic Intellectual Disability

Developmental And Epileptic Encephalopathy 24

DEE24	Epileptic Encephalopathy, Early Infantile, 24
Eiee24	Developmental And Epileptic Encephalopathy, 24
Early Infantile Epileptic Encephalopathy 24	Encephalopathy, Epileptic, Early Infantile, Type 24

Leber Optic Atrophy And Dystonia

LDYT	Marsden Syndrome
Leber Hereditary Optic Neuropathy With Dystonia	Leber Hereditary Optic Neuropathy And Dystonia
Familial Dystonia With Visual Failure And Striatal Lucencies	Dystonia, Familial, With Visual Failure And Striatal Lucencies
Leber Optic Atrophy With Dystonia	Dystonia Familial, With Visual Failure And Striatal Lucencies
Lhon And Dystonia	Leber'S Hereditary Optic Neuropathy With Dystonia

Primary Progressive Multiple Sclerosis

Ppms	Primary-Progressive Ms
Multiple Sclerosis, Primary Progressive

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Pelizaeus-Merzbacher Disease

PMD	HLD1
Pelizaeus-Merzbacher Brain Sclerosis	Leukodystrophy, Hypomyelinating, 1
Diffuse Familial Brain Sclerosis	Pelizaeus Merzbacher Brain Sclerosis
Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type	Cockayne-Pelizaeus-Merzbacher Disease
Hypomyelinating Leukodystrophy 1	Leukodystrophy, Sudanophilic
Pelizaeus Merzbacher Disease	Hypomyelinating Leukodystrophy, 1
Sudanophilic Leukodystrophy	Pelizaeus-Merzbacher Disease, Connatal Form
Connatal Pmd	Pelizaeus-Merzbacher Disease Type Ii
Severe Pmd	Null Syndrome
Plp1 Null Syndrome	Pelizaeus-Merzbacher Disease, Null Syndrome
Brain Sclerosis Diffuse Familial	Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type
Leukodystrophy Hypomyelinating 1	Diffuse Cerebral Sclerosis Of Schilder

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07680	LINGO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LINGO1	VGNC	VGNC:74094
Bos taurus	LINGO1	VGNC	VGNC:30899
Canis familiaris	LINGO1	VGNC	VGNC:42688
Felis catus	LINGO1	VGNC	VGNC:63236
Mus musculus	LINGO1	MGD	MGI:1915522
Rattus norvegicus	LINGO1	RGD	RGD:1308668

Name
Email *

	Sorry, but the email address you supplied was invalid.