2. Gene
  3. SPAG5 - sperm associated antigen 5 Gene

SPAG5 - sperm associated antigen 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as MAP126; DEEPEST; hMAP126

Gene ID: 10615 | Gene type: protein coding

About SPAG5

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,577,574-28,599,025 (from NCBI)

This gene has 16 transcripts (splice variants) and 129 orthologues. Biased expression in testis (RPKM 49.5), bone marrow (RPKM 14.3) and 9 other tissues.

Summary

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]

SPAG5 Products(1)

mRNA Protein Name
NM_006461.4 NP_006452.3 sperm-associated antigen 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables microtubule binding IDA
IDA: Inferred from direct assay
27462074 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18361916 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromosome segregation IMP
IMP: Inferred from mutant phenotype
21402792 GOA
involved in mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
21402792 GOA
involved in positive regulation of intracellular transport IMP
IMP: Inferred from mutant phenotype
27462074 GOA
involved in positive regulation of spindle assembly IMP
IMP: Inferred from mutant phenotype
27462074 GOA
involved in protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
26297806 GOA
involved in regulation of attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
21402792 GOA
involved in regulation of metaphase plate congression IMP
IMP: Inferred from mutant phenotype
27462074 GOA
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
21402792 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centriolar satellite IMP
IMP: Inferred from mutant phenotype
26297806 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
27462074 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
21402792 GOA
located in microtubule plus-end IDA
IDA: Inferred from direct assay
21402792 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
21402792 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
27462074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm-associated antigen 5

astrin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13624 SPAG5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPAG5 MGD MGI:1927470
Rattus norvegicus SPAG5 RGD RGD:620152
Felis catus SPAG5 VGNC VGNC:99460
Macaca mulatta SPAG5 VGNC VGNC:99266
Canis familiaris SPAG5 VGNC VGNC:99672
Bos taurus SPAG5 VGNC VGNC:55873