SPAG5 - sperm associated antigen 5 Gene

Homo sapiens

Also known as MAP126; DEEPEST; hMAP126

Gene ID: 10615 | Gene type: protein coding

About SPAG5

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,577,574-28,599,025 (from NCBI)

This gene has 16 transcripts (splice variants) and 129 orthologues. Biased expression in testis (RPKM 49.5), bone marrow (RPKM 14.3) and 9 other tissues.

Summary

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]

SPAG5 Products(1)

mRNA	Protein	Name
NM_006461.4	NP_006452.3	sperm-associated antigen 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	27462074	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18361916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	21402792	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	21402792	GOA
involved in positive regulation of intracellular transport	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in positive regulation of spindle assembly	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	26297806	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	21402792	GOA
involved in regulation of metaphase plate congression	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	21402792	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IMP IMP: Inferred from mutant phenotype	26297806	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	27462074	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	21402792	GOA
located in microtubule plus-end	IDA IDA: Inferred from direct assay	21402792	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	21402792	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	27462074	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sperm-associated antigen 5

astrin

SPAG5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPAG5	Q96R06	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	SPAG5	Q96R06	ZNF572	Homo sapiens	Q7Z3I7	Y2H Array	32296183
Intra	SPAG5	Q96R06	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	SPAG5	Q96R06	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	SPAG5	Q96R06	GOLGA8F	Homo sapiens	Q08AF8	Validated Y2H	25416956
Intra	SPAG5	Q96R06	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	SPAG5	Q96R06	GOLGA8DP	Homo sapiens	Q0D2H9	Validated Y2H	25416956
Intra	SPAG5	Q96R06	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Array	25416956
Intra	SPAG5	Q96R06	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
Intra	SPAG5	Q96R06	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	SPAG5	Q96R06	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	SNAP47	Homo sapiens	Q5SQN1	Y2H Array	25416956
Intra	SPAG5	Q96R06	SNAP47	Homo sapiens	Q5SQN1	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	25416956
Intra	SPAG5	Q96R06	CDC20B	Homo sapiens	Q86Y33	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	CDC20B	Homo sapiens	Q86Y33	Y2H Array	25416956
Intra	SPAG5	Q96R06	LGALS14	Homo sapiens	Q8TCE9	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	LGALS14	Homo sapiens	Q8TCE9	Validated Y2H	25416956
Intra	SPAG5	Q96R06	LGALS14	Homo sapiens	Q8TCE9	Y2H Array	25416956
Intra	SPAG5	Q96R06	RPTOR	Homo sapiens	Q8N122	PLA	23953116
Intra	SPAG5	Q96R06	HAUS1	Homo sapiens	Q96CS2	Y2H Array	25416956
Intra	SPAG5	Q96R06	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	SPAG5	Q96R06	OSBPL8	Homo sapiens	Q9BZF1	Confocal	24424245
Intra	SPAG5	Q96R06	POLR2L	Homo sapiens	P62875	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	ORC6	Homo sapiens	Q9Y5N6	Y2H Array	25416956
Intra	SPAG5	Q96R06	ORC6	Homo sapiens	Q9Y5N6	Y2H Array	31515488
Intra	SPAG5	Q96R06	EIF4E2	Homo sapiens	O60573	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	SPAG5	Q96R06	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	25416956
Intra	SPAG5	Q96R06	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	SPAG5	Q96R06	TTC23	Homo sapiens	Q5W5X9	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	ZFC3H1	Homo sapiens	G3V1X1	Validated Y2H	25416956
Intra	SPAG5	Q96R06	LINGO1	Homo sapiens	Q96FE5	Validated Y2H	25416956
Intra	SPAG5	Q96R06	LINGO1	Homo sapiens	Q96FE5	Y2H Array	25416956
Intra	SPAG5	Q96R06	KANSL1	Homo sapiens	Q7Z3B3	Validated Y2H	25416956
Intra	SPAG5	Q96R06	ZC2HC1C	Homo sapiens	Q53FD0	Y2H Array	25416956
Intra	SPAG5	Q96R06	ZC2HC1C	Homo sapiens	Q53FD0	Validated Y2H	25416956
Intra	SPAG5	Q96R06	RBM41	Homo sapiens	Q96IZ5	Validated Y2H	25416956
Intra	SPAG5	Q96R06	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
Intra	SPAG5	Q96R06	CHCHD3	Homo sapiens	Q9NX63	Y2H Array	25416956
Intra	SPAG5	Q96R06	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	SH2D4A	Homo sapiens	Q9H788	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
Intra	SPAG5	Q96R06	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	SPAG5	Q96R06	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	SPAG5	Q96R06	DCX	Homo sapiens	O43602	Validated Y2H	25416956
Intra	SPAG5	Q96R06	DCX	Homo sapiens	O43602	Y2H Array	25416956
Intra	SPAG5	Q96R06	TSHZ3	Homo sapiens	Q63HK5	Y2H Prey Pooling	25416956
Intra	SPAG5	Q96R06	BARD1	Homo sapiens	A0AVN2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13624	SPAG5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPAG5	MGD	MGI:1927470
Rattus norvegicus	SPAG5	RGD	RGD:620152
Felis catus	SPAG5	VGNC	VGNC:99460
Macaca mulatta	SPAG5	VGNC	VGNC:99266
Canis familiaris	SPAG5	VGNC	VGNC:99672
Bos taurus	SPAG5	VGNC	VGNC:55873

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