ZNF341 - zinc finger protein 341 Gene

Homo sapiens

Also known as HIES3

Gene ID: 84905 | Gene type: protein coding

About ZNF341

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:33,731,996-33,792,269 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 1.6), spleen (RPKM 1.5) and 25 other tissues.

Summary

Enables DNA binding activity and DNA-binding transcription activator activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. Implicated in hyper IgE recurrent Infection syndrome 3. [provided by Alliance of Genome Resources, Apr 2022]

ZNF341 Products(3)

mRNA	Protein	Name
NM_001282933.2	NP_001269862.1	zinc finger protein 341 isoform 1
NM_001282935.2	NP_001269864.1	zinc finger protein 341 isoform 3
NM_032819.5	NP_116208.3	zinc finger protein 341 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	29907690	GOA
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	29907690	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	29907690	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF341 Protein Structure

zf-C2H2_6

zf-H2C2_2

zf-C2H2_4

zf-C2H2_6

zf-C2H2

zf-C2H2_4

zf-H2C2_2

0
200
400
600
800
854 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 341

ZNF341 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF341	Q9BYN7	C11orf68	Homo sapiens	Q9H3H3-3	Validated Y2H	32296183
Intra	ZNF341	Q9BYN7	KLHL38	Homo sapiens	Q2WGJ6	Y2H Array	25416956
Intra	ZNF341	Q9BYN7	CSTF2	Homo sapiens	P33240	Y2H Array	25416956
Intra	ZNF341	Q9BYN7	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	ZNF341	Q9BYN7	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hyper-Ige Recurrent Infection Syndrome 3, Autosomal Recessive

HIES3

Hyper Ige Recurrent Infection Syndrome 3

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Immunodeficiency 63 With Lymphoproliferation And Autoimmunity

IMD63	Il2rb Deficiency
Cd122 Deficiency	Immunodeficiency 63
Interleukin 2 Receptor, Beta, Deficiency Of	Deficiency Of Interleukin 2 Receptor Beta

Hyper Ige Recurrent Infection Syndrome 1

Job Syndrome	Hyper-Ige Recurrent Infection Syndrome 1
Hyperimmunoglobulin E Syndrome	Job'S Syndrome
Recurring Cold Staphylococcal Abscesses	Ige Syndromes
Buckley Syndrome	Hie - [Hyperimmunoglobulin E] Syndrome
Job-Buckley Syndrome	Quie-Hill Syndrome

Immunodeficiency 35

Tyrosine Kinase 2 Deficiency	IMD35
Tyk2 Deficiency	Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis
Susceptibility To Infection Due To Tyk2 Deficiency	Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive
Hies With Atypical Mycobacteriosis, Autosomal Recessive	Autosomal Recessiv Hies With Atypical Mycobacteriosis
Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency	Autosomal Recessive Hies With Atypical Mycobacteriosis

Immunodeficiency 11

Immunodeficiency 11a	Severe Combined Immunodeficiency Due To Card11 Deficiency
IMD11A	Imd11
Card11 Immunodeficiency	Scid Due To Card11 Deficiency
Card11 Deficiency	Immunodeficiency 11 A

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

T Cell And Nk Cell Immunodeficiency

Hepatic Venoocclusive Disease With Immunodeficiency

VODI	Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatic Veno-Occlusive Disease With Immunodeficiency	Familial Veno-Occlusive Disease With Immunodeficiency
Veno-Occlusive Disease And Immunodeficiency Syndrome	Vodi Syndrome
Vodi - [Veno-Occlusive Disease Immunodeficiency] Syndrome

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16128	ZNF341 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZNF341	VGNC	VGNC:37253
Mus musculus	ZNF341	MGD	MGI:2682937
Macaca mulatta	ZNF341	VGNC	VGNC:79001
Felis catus	ZNF341	VGNC	VGNC:67292
Rattus norvegicus	ZNF341	RGD	RGD:1564726
Canis familiaris	ZNF341	VGNC	VGNC:48705

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